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  Vincenzo A. Gennarino  

Vincenzo A. Gennarino, Ph.D. Post-doc

Phone: 713-798-6695
Email: gennarin@bcm.edu

Joined the lab: 2010

 
     
 

Education:

2005: Graduation in Biological Science cum laude,"A. Monroy" University of Palermo, Italy. Grade: summa cum laude
2009: Ph.D. in Medical Genetics at Telethon Institute of Genetics and Medicine (TIGEM), Second University of Naples, Italy.

 
     
 

Projects:

  1. Characterize the molecular mechanisms in spinocerebellar ataxia type 1.

Spinocerebellar ataxia type 1 (SCA1) is one of nine diseases in which a polyglutamine (CAG) expansion causes the disease protein to misfold, accumulate and exert various toxic functions. As such, it is also part of the larger family of protein misfolding neurodegenerative diseases, such as Parkinson and Alzheimer disease, and insights into SCA1 have often shed light on these more common conditions. We have made a number of discoveries that reveal SCA1 pathogenesis to be considerably more complex than anyone expected. The our ultimate goal is to develop effective therapies. The aim of my fellowship is to understand and characterize by in vivo studies the molecular mechanisms that underlie differential neuronal vulnerability in SCA1.

 

 
  Comments:
I have worked in miRNA field, especially for microRNA target predictions, during my PhD. course. Now, I am interested and motivated in neuronal disorder research by in vivo studies using mouse as model system.

 
 

Selected publications:

Gennarino VA, D’angelo G, Dharmalingam G, Fernandez S, Russolillo G, Sanges R, Mutarelli M, Belcastro V, Ballabio A, Verde P, Sardiello M, Banfi S. Identification of microRNA-regulated gene networks by expression analysis of target genes. Genome Res. 2012 Feb 14.

Gennarino VA*, Sardiello M, Mutarelli M, Dharmalingam G, Maselli V, Lago G and Banfi S. (*corresponding author). HOCTAR database: a unique resource for microRNA target prediction. Gene. 2011 Jul 1;480(1-2):51-8. Epub 2011 Mar 22.

Karali M , Peluso I, Gennarino VA, Bilio M, Verde R, Lago G, Dollé P, Banfi S. (co-first author). miRNeye: a microRNA expression atlas of the mouse eye. BMC Genomics. 2010 Dec 11:715. Highly Accessed

Licastro D*, Gennarino VA*, Petrera F, Sanges R, Banfi S and Stupka E. (*co-first author). The majority of ultra conserved elements acting as enhancers is transcribed. BMC Genomics. 2010 Mar 4;11(1):151. Highly Accessed.

Grillo G, Turi A, Licciulli F, Mignone F, Liuni S, Banfi S, Gennarino VA, Horner DS, Pavesi G, Picardi E, Pesole G. UTRdb and UTRsite (release 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.Nucleic Acids Res. 2010 Jan;38 (Database issue):D75-80. Epub 2009 Oct 30.

Meola N, Gennarino VA and Banfi S. microRNAs and genetic diseases.Pathogenetics. 2009 Nov 4;2(1):7. Highly Accessed.

Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, Banfi S, Parenti G, Cattaneo E, Ballabio A.  A gene network regulating lysosomal biogenesis and function. Science. 2009 Jul 24;325(5939):473-7. Epub 2009 Jun 25.

Gennarino VA, Sardiello M, Avellino R, Meola N, Maselli V, Anand S, Cutillo L, Ballabio A and Banfi S.MicroRNA target prediction by expression analysis of host genes. Genome Res. 2009 Mar;19(3):481-90. Epub 2008 Dec 16.

 
  Hobbies or Interests:
In my free time I love decorating my home and cooking new dishes I create. I worked two years in Tunis in the wine field and so this experience has strengthened my passion for the wine. I love many sports as well as football, billiards, basketball and athletics.
 
     


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Last Modified: August, 2010