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Zechiedrich Laboratory

Houston, Texas

Supercoils in architecture echo the structure of DNA.
Zechiedrich Lab
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Michael A. Evangelista

Photo Kimberly Carlson

Graduate Student
March 2011 - Present
Verna and Marrs McLean Department of Biochemistry and Molecular Biology

E-mail:evangeli@bcm.edu
Phone: 713-798-5127
Fax: 713-798-7375

Research Interest
Drug-resistant bacterial infections cost many lives and billions of dollars each year yet the fundamental molecular mechanisms underlying the occurrence of antibiotic resistance remain obscure. Based on analysis of the Escherichia coli pan-genome we have identified SNPs that are correlated with fluoroquinolone resistance in clinical isolates. My goal is investigate whether these SNPs contribute to a mechanism for promoting antibiotic resistance in pathogens.

Awards
2007 – American Society for Microbiology Undergraduate Research Fellowship

Professional Societies
American Society for Microbiology (2007 – Present)

Talks/Poster Presentations

Talk and Poster - 108th General Meeting of the American Society for Microbiology June 1-5, 2008
Poster - 112th Annual Meeting of the American Society for microbiology June 16-20, 2012

Publications
Michelle C. Swick, Michael A. Evangelista equal contributor, Truston J. Bodine equal contributor, Jeremy R. Easton-Marks, Patrick Barth, Minita J. Shah, Christina A. Bormann Chung ,Sarah Stanley, Stephen F. McLaughlin, Clarence C. Lee, Vrunda Sheth, Quynh Doan, Richard J. Hamill, Lynn Zechiedrich Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates. PLoS ONE 8(6): e65961. doi:10.1371/journal.pone.0065961

Yakhnin H, Baker CS, Berezin I, Evangelista MA, Rassin A, Romeo T, Babitzke P.. CsrA represses translation of sdiA, encoding the N-acylhomoserine-L-lactone receptor of Escherichia coli, by binding exclusively within the coding region of sdiA mRNA. J. Bacteriol. 2011 193(22) 6162-6170.

Swick, M.C., Easton-Marks, J.R., Evangelista, MA, Shah, M.J., Bormann Chung, C.A., Stanley, S., McLaughlin, S.F., Lee, C.C., Sheth, V., Doan, Q., Hamill, R.J., Steffen, D., Becnel, L.B., Sucgang, R., and Zechiedrich, L. Conserved genomic variations in E. coli clinical isolates correlate with fluoroquinolone resistance phenotypes. (submitted)

Alpadi, K., Kulkarin, A., Namjoshi, S., Srinivasan, S., Ayscough, K., Zieger, M., Evangelista, M., Quiocho, F.A., and Peters, C.. Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion. (submitted)