About the Lab

The Zechiedrich laboratory was established in August 1997.

Our location in the largest medical center in the world makes us ideally suited for taking a systems approach combating antibiotic resistance. This work was initially funded by a new investigator award from the Burroughs Wellcome Fund, was supplemented by an award from Applied Biosystems, and has been NIH funded since 2004.

Our laboratory also works to understand the bacterial targets of fluoroquinolones, and cancer target therapeutics, the DNA topoisomerases. Because the essential topoisomerases modulate DNA (work first funded by the National Science Foundation), the work in our laboratory has broadened to include creating tiny circles of DNA to study DNA supercoiling and how it affects topoisomerases and how drugs inhibit topoisomerases. These tiny circles of DNA have proven to be extremely efficient gene therapy vectors. We received an award from the John S. Dunn Foundation, a collaborative grant from the international Human Frontier Science Program, seed funding from the Northwest Genome Engineering Consortium in Seattle, and seed funding from the Baylor–UT Houston Center for AIDS Research on this project, which is currently funded by the NIH.

The multidisciplinary research in the laboratory provides ample opportunity for trainees. Dr. Zechiedrich has trained 10 postdoctoral fellows, 16 graduate students, three post-baccalaureate students, 19 undergraduate students, and three high school students. She has published and lectured nationally on mentoring and was Baylor College of Medicine’s BRASS Mentor of the Year in 2013. Former trainees from the Zechiedrich lab now contribute to science in multiple different capacities. They are college professors, company scientists and CEO's, medical doctors, science writers, postdoctoral fellows, or are involved in K12 education.