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Goodell Laboratory

Houston, Texas

A BCM research lab.
Goodell Lab
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Publications

2012

  • Mayle A, Luo M, Jeong M, Goodell MA. Flow cytometry analysis of murine hematopoietic stem cells. Cytometry A. 2012. [Pubmed]
  • Li J, Harris RA, Cheung SW, Coarfa C, Jeong M, Goodell MA, White LD, Patel A, Kang SH, Shaw C, Chinault AC, Gambin T, Gambin A, Lupski JR, Milosavljevic A. Plos Genetics. 2012. 8(5):e1002692. [Pubmed]
  • James RA, Rao MM, Chen ES, Goodell MA, Shaw CA. The hematopoietic expression viewer: expanding mobile apps as a scientific tool. Bioinformatics. 2012 28(14):1941-2. [Pubmed]
  • Zohren F, Souroullas GP, Luo M, Gerdemann U, Imperato MR, Wilson NK, Gottgens B, Lukov GL, Goodell MA. The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nature Immunology. 2012 13(8):761-9. [Pubmed]
  • Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood. 2012 Mar 15;119(11):2500-9. [Pubmed]

2011

  • Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011 Dec 4;44(1):23-31. [Pubmed]
  • Berg JS, Lin KK, Sonnet C, Boles NC, Weksberg DC, Nguyen H, Holt LJ, Rickwood D, Daly RJ, Goodell MA. Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One. 2011;6(10):e26410. [Pubmed]
  • Challen GA, Goodell MA. [Editorial] Bridge over troubled stem cells. Mol Ther. 2011 Oct;19(10):1756-8. [Pubmed]
  • Lin KK, Rossi L, Boles NC, Hall BE, George TC, Goodell MA. CD81 is essential for reentry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt-pathway. PLoS Biol. 2011 Sep;9(9):e1001148. [Pubmed]
  • King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011 Sept 9. [Pubmed]
  • Souroullas GP, Goodell MA. A new allele of Lyl1 confirms its important role in hematopoietic stem cell function. Genesis. 2011 Jun;49(6):441-8. [Pubmed]
  • King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, Goodell MA. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood 2011 Aug 11; 118(6):1525-33. [Pubmed]
  • Liao J, Hammerick KE, Challen GA, Goodell MA, Kasper FK, Mikos AG. Investigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro. J Orthop Res. 2011 Oct;29(10):1544-53. [Pubmed]
  • Rossi L, Ergen AV, Goodell MA. TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs. Blood. 2011 Jun 16;117(24):6479-88. [Pubmed]
  • Boles NC, Lin KK, Lukov GL, Bowman TV, Baldridge MT, Goodell MA. CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. Blood. 2011 Jul 7;118(1):80-7.[Pubmed]
  • Rossi L, Challen GA, Sirin O, Lin KK, Goodell MA. Hematopoietic stem cell characterization and isolation.Methods Mol Biol. 2011;750:47-59. [Pubmed]
  • Lin KK, Goodell MA. Detection of hematopoietic stem cells by flow cytometry. Methods Cell Biol. 2011;103:21-30. [Pubmed]
  • King KY, Goodell MA. [Editorial] Direct conversion of skin cells into blood: alchemy or science? Molecular Therapy. 2011. Feb;19(2):227-8. [Pubmed]
  • King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MA. Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS One. 2011 Jan;6(1):e16317. [Pubmed]
  • Baldridge MT, King KY, Goodell MA. [Review] Inflammatory signals regulate hematopoietic stem cells. Trends in Immunology. 2011 Jan;32(2):57-65. [Pubmed]

2010

  • Sirin O, Lukov G, Mao R, Conneely O, Goodell MA. The Orphan Nuclear Receptor Nurr1 Restricts the Proliferation of Hematopoietic Stem Cells. Nature Cell Biology. 2010 Dec;12(12):1213-9. [Pubmed]
  • Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MA. LYL1 degradation by the proteosome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PLoS One. 2010 Sept 10;5(9). [Pubmed]
  • Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MA. The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation. Leuk Res. 2010 Aug 10. [Pubmed]
  • Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010 Jun 10;465(7299):793-7. [Pubmed]
  • Challen GA, Boles NC, Chambers SM, Goodell MA. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell. 2010 Mar 5;6(3):265-278. [PubMed] link to article

2009

  • Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, and Goodell MA , Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell. 2009 Feb; 4(2):180-6. [PubMed]
  • Challen GA, Boles N, Lin KK, and Goodell MA [Review], Mouse hematopoietic stem cell identification and analysis. Cytometry A. 2009 Jan; 75(1):14-24. [PubMed]

2008

  • Vieyra D, Rosen A, and Goodell MA, Identification and Characterization of SP Cells in ESC Cultures. Stem Cells Dev. 2008 Dec 29. [PubMed]
  • Challen GA and Goodell MA, Promiscuous expression of H2B-GFP transgene in hematopoietic stem cells. PLoS One. 2008 Jun 4; 3(6):e2357. [PubMed]
  • Weksberg DC, Chambers SM, Boles NC, and Goodell MA, CD150 negative Side Population cells represent a functionally distinct long term hematopoietic stem cell population. Blood. 2008 Feb 15; 111(4):2444-51. [Blood]
  • Yankelevich M, Goodell MA, and Kaplan J, Efficacy of delayed administration of post-chemotherapy granulocyte colony-stimulating factor: evidence from murine studies of bone marrow cell kinetics. Exp Hematol. 2008 Jan; 36(1):9-16. [PubMed]
  • Feng CG, Weksberg DC, Taylor GA, Sher A, and Goodell MA, The p47 GTPase Lrg-47 (Irgm1) links hematopoietic stem cell proliferation and host defense. Cell Stem Cell. 2008 Jan 10; 2(1):83-9. [PubMed]

2007

  • Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA,Sirin O,Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, and Goodell MA. Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their Progeny. [Resource]. Cell Stem Cell Vol 1, 578–591, November 2007 [Cell Stem Cell].
  • Berg JS and Goodell MA. [Preview], An Argument against a Role for Oct4 in Somatic Stem Cells. Cell Stem Cell 2007 Vol 1, Oct 11 2007 [Cell Stem Cell]
  • Chambers SM and Goodell MA. [Review]. Hematopoietic stem cell aging: wrinkles in stem cell potential. Stem Cell Rev. 2007 Sep;3(3):201-11 [PubMed]
  • Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007 Aug;5(8):e201. [PubMed]
  • Bowman TV, Merchant AA, Goodell MA. [Review]. Molecular profiling of hematopoietic stem cells. Methods Mol Med. 2007;134:1-16. [PubMed]
  • Vieyra DS, Goodell MA. Pluripotentiality and Conditional Transgene Regulation In Human Embryonic Stem Cells Expressing Insulated Tet-on Transactivator. Stem Cells. 2007 Jul 12; [PubMed]
  • Kustikova OS, Geiger H, Li Z, Brugman MH, Chambers SM, Shaw CA, Pike-Overzet K, de Ridder D, Staal FJ, von Keudell G, Cornils K, Nattamai KJ, Modlich U, Wagemaker G, Goodell MA, Fehse B, Baum C. Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood. 2007 Mar 1;109(5):1897-907. Epub 2006 Nov 21. [PubMed]
  • Dumble M, Moore L, Chambers SM, Geiger H, Van Zant G, Goodell MA, Donehower LA.. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood. 2007 Feb 15;109(4):1736-42. Epub 2006 Oct 10. [PubMed]

2006

  • Lin KK, Goodell MA., [book chapter] Purification of hematopoietic stem cells using the side population. Methods Enzymol. 2006;420:255-64. [PubMed]
  • Civin CI, Gewirtz AM, Goodell MA, Hawley RG, Murphy Jr MJ. [Editorial] Editorial Retraction. Stem Cells. 2006 Apr 2; [PubMed]
  • Ramos CA, Bowman TA, Boles NC, Merchant AA, Zheng Y, Parra I, Fuqua SA, Shaw CA, Goodell MA. Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2006 Sep 29;2(9):e159. Epub 2006 Aug 9.; [PubMed]
  • Civin CI, Gewirtz AM, Hawley RG, Goodell MA. [Editorial] Stem cells journal: robust growth in 2005. Stem Cells. 2006 Jan;24(1):1-2.
  • Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar;24(3):662-70. [PubMed]
  • Camargo FD, Chambers SM, Drew E, McNagny KM, Goodell MA. Hematopoietic stem cells do not engraft with absolute efficiencies. Blood. 2006 Jan 15;107(2):501-7. [PubMed]

2005

  • Bradfute SB, Graubert TA, Goodell MA. Roles of Sca-1 in hematopoietic stem/progenitor cell function. Exp Hematol. 2005 Jul;33(7):836-43. [PubMed]
  • Vieyra DS, Jackson KA, Goodell MA. [Review] Plasticity and tissue regenerative potential of bone marrow-derived cells.Stem Cell Rev. 2005;1(1):65-9; [PubMed]
  • Civin CI, Gewirtz AM, Hawley RG, Goodell MA. [Editorial] Open access, rapid publishing: no longer a thing of the future. Stem Cells. 2005 Apr;23(4):456-7.
  • Hirschmann-Jax C, Foster AE, Wulf GG, Goodell MA, Brenner MK. A distinct "side population" of cells in human tumor cells: implications for tumor biology and therapy. Cell Cycle. 2005 Feb;4(2):203-5. [PubMed]
  • Civin CI, Gewirtz AM, Hawley RG, Goodell MA. Advancing the fast-paced field of stem cell research: Stem Cells increases from 6 to 10 issues in its 23rd year of publication. Stem Cells. 2005;23(1):1-2. [PubMed]

2004

  • Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct;2(10):e301. [PubMed]
  • Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33. [PubMed]
  • Goodell MA, McKinney-Freeman S, Camargo FD. Isolation and characterization of side population cells. Methods Mol Biol. 2005;290:343-52. [PubMed]
  • McKinney-Freeman S, Goodell MA. Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis. Exp Hematol. 2004 Sep;32(9):868-76. [PubMed]
  • Camargo FD, Finegold M, Goodell MA. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest. 2004 May;113(9):1266-70. [PubMed]
  • Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 2004 May 11;43(18):5352-9. [PubMed]
  • Jackson KA, Snyder DS, Goodell MA. Skeletal muscle fiber-specific green autofluorescence: potential for stem cell engraftment artifacts. Stem Cells. 2004;22(2):180-7. [PubMed]
  • Camargo FD, Chambers SM, Goodell MA [Review] Stem cell plasticity: from transdifferentiation to macrophage fusion. Cell Prolif. 2004 Feb;37(1):55-65. [PubMed]
  • Norwood K, Wang RY, Hirschmann-Jax C, Andreeff M, Brenner MK, Goodell MA, Wulf GG. An in vivo propagated human acute myeloid leukemia expressing ABCA3. Leuk Res. 2004 Mar;28(3):295-9. [PubMed]

2003

  • Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis AR. Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15877-82. [PubMed]
  • Goodell MA [Overview] Stem cells: technologies for the future. Biotechniques 2003 Dec;35(6):1232. [link]
  • Daley GQ, Goodell MA, Snyder EY [Review] Realistic prospects for stem cell therapeutics. Hematology (Am Soc Hematol Educ Program). 2003;:398-418. [PubMed]
  • Camargo FD, Green R, Capetanaki Y, Jackson KA, Goodell MA. Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med. 2003 Dec;9(12):1520-7. [PubMed]
  • Welm B, Behbod F, Goodell MA, Rosen JM [Review] Isolation and characterization of functional mammary gland stem cells. Cell Prolif. 2003 Oct;36 Suppl 1:17-32. [PubMed]
  • Jackson KA and Goodell MA. [book chapter] Generation and Stem Cell Repair of Cardiac Tissue. In: Stem Cells Handbook; S. Sell (Ed). Humana Press, NJ 2003 Oct; pp 259-266. [link]
  • McKinney-Freeman SL, Majka SM, Jackson KA, Norwood K, Hirschi KK, Goodell MA. Altered phenotype and reduced function of muscle-derived hematopoietic stem cells. Exp Hematol. 2003 Sep;31(9):806-14. [PubMed]
  • Oliveira DM, Goodell MA. Transient RNA interference in hematopoietic progenitors with functional consequences. Genesis. 2003 Aug;36(4):203-8. [PubMed]
  • Nadin BM, Goodell MA, Hirschi KK. Phenotype and hematopoietic potential of side population cells throughout embryonic development. Blood. 2003 Oct 1;102(7):2436-43. [PubMed]
  • Brenner MK, Wulf GG, Rill DR, Luo KL, Goodell MA, Mei Z, Kuehnle I, Brown MP, Pule M, Heslop HE, Krance RA. Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man. Ann N Y Acad Sci. 2003 May;996:80-8. [PubMed]
  • Goodell MA [Review] Stem-cell "plasticity": befuddled by the muddle. Curr Opin Hematol. 2003 May;10(3):208-13. [PubMed]
  • Wulf GG, Luo KL, Jackson KA, Brenner MK, Goodell MA. Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells. Haematologica. 2003 Apr;88(4):368-78. [PubMed]
  • Bradfute SB, Goodell MA. Adenoviral transduction of mouse hematopoietic stem cells. Mol Ther. 2003 Mar;7(3):334-40. [PubMed]
  • Ramos CA, Venezia TA, Camargo FA, Goodell MA [Review] Techniques for the study of adult stem cells: be fruitful and multiply. Biotechniques. 2003 Mar;34(3):572-8, 580-4, 586-91. [PubMed]
  • Wulf GG, Luo KL, Goodell MA, Brenner MK. Anti-CD45-mediated cytoreduction to facilitate allogeneic stem cell transplantation. Blood. 2003 Mar 15;101(6):2434-9. [PubMed]
  • Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD. Response to comment on "Failure of bone marrow cells to transdifferentiate into neural cells in vivo." Science. 2003 Feb 21;299:1184c. [PubMed]
  • Ramos CA, Zheng Y, Colombowala I, Goodell MA. Tracing the origin of non-hematopoietic cells using CD45 PCR restriction fragment length polymorphisms. Biotechniques. 2003 Jan;34(1):160-2. [PubMed]
  • Majka SM, Jackson KA, Kienstra KA, Majesky MW, Goodell MA, Hirschi KK. Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. J Clin Invest. 2003 Jan;111(1):71-9. [PubMed]

2002

  • Goodell MA [Review] Multipotential stem cells and 'side population' cells. Cytotherapy. 2002;4(6):507-8. [PubMed]
  • Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD. Response to "Something in the eye of the beholder" Science. 2002 Oct 11;298:362. [PubMed]
  • Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD. Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science. 2002 Aug 23;297:1299. [PubMed]
  • Kuehnle I, Goodell MA [Review] The therapeutic potential of stem cells from adults. BMJ. 2002 Aug 17;325(7360):372-6. [PubMed]
  • Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MA. Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol. 2002 Jul;30(7):809-15. [PubMed]
  • Jackson KA, Majka SM, Wulf GG, Goodell MA [Review] Stem cells: a minireview. J Cell Biochem Suppl. 2002;38:1-6. [PubMed]
  • Hirschi KK, Goodell MA [Review] Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells. Gene Ther. 2002 May;9(10):648-52. [PubMed]
  • Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA. Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol. 2002 May 1;245(1):42-56. [PubMed]
  • McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1341-6. [PubMed]

2001

  • Wulf GG, Jackson KA, Goodell MA [Review]. Somatic stem cell plasticity: current evidence and emerging concepts. Exp Hematol. 2001 Dec;29(12):1361-70. [PubMed]
  • Goodell MA [Review] Stem cells: is there a future in plastics? Curr Opin Cell Biol. 2001 Dec;13(6):662-5. [PubMed]
  • Wulf GG, Wang RY, Kuehnle I, Weidner D, Marini F, Brenner MK, Andreeff M, Goodell MA. A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood. 2001 Aug 15;98(4):1166-73. [PubMed]
  • Goodell MA, Jackson KA, Majka SM, Mi T, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK [Review]. Stem cell plasticity in muscle and bone marrow. Ann N Y Acad Sci. 2001 Jun;938:208-18; discussion 218-20. [PubMed]
  • Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 2001 Jun;107(11):1395-402. [PubMed]
  • Goodell MA [Commentary] Dynamic CD34 expression Blood 2001 Jan;97(2):337. [link]

2000

  • Storms RW, Goodell MA, Fisher A, Mulligan RC, Smith C. Hoechst dye efflux reveals a novel CD7(+)CD34(-) lymphoid progenitor in human umbilical cord blood. Blood. 2000 Sep 15;96(6):2125-33. [PubMed]

1999

  • Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14482-6. [PubMed]
  • Goodell MA. Introduction: Focus on hematology. CD34(+) or CD34(-): does it really matter? Blood. 1999 Oct 15;94(8):2545-7. [PubMed]

1997

  • Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med. 1997 Dec;3(12):1337-45. [PubMed]

1996

  • Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996 Apr 1;183(4):1797-806. [PubMed

1992

  • Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. Effects of an Rb mutation in the mouse. Nature. 1992 Sep 24;359(6393):295-300. [PubMed]

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