June 23-27, 2014
Max Delbrück Center (MDC) for Molecular Medicine
Berlin, Germany

The Analysis of Next Generation Sequence Data Course was held at the MDC in Berlin from June 23-27, 2014. The goal of the course is to teach the course participants both the theory and application of methods to analyze next generation sequence (NGS) data for human traits. Attendees will learn how to design studies, call variants from NGS data, analyze population- and family-based sequence data and evaluate variant functionality. Analyses will include performing complex trait rare variant association analysis for population and trio data and also identifying variants for Mendelian traits. Exercises will be carried out using a variety of computer programs (GATK, IGV, Polyphen2, PSEQ, SEQPower, and Variant Association Tools (VAT)). TOPICS will be include: sequence alignment, calling variants from NGS data, population genetics (purifying selection, drift, etc), quality control of NGS data, association testing framework for quantitative and qualitative traits, rare variant association methods, estimating power and sample size for rare variant association tests, imputation of rare variants, detecting putative causal variants for Mendelian traits and evaluating variant functionality. The instructors for the course are Laurent Francioli (University Medical Center Utrecht), Suzanne Leal (Baylor College of Medicine), Michael Nothnagel (University of Cologne) and Peter Nick Robinson (Charité).

The cost of the 5 day course is 975 EUR for researchers from an academic institution, and 1,950 EUR for individuals from private (for profit) companies. This fee covers tuition, Monday evening wine and cheese party and course related expenses (handouts, etc.) but not room, board or meals. Inexpensive housing is available for course participants at the MDC and nearby hotels.

For additional information on the Genetic Association Course please contact Suzanne Leal:

Email: sleal@bcm.edu
Phone: +1 (713) 798-4011
Fax: +1 (713) 798-4012