About the Lab

Bettini Lab Members (320x240)
Bettini Lab Members

Our lab's research interests are in the area of autoimmune diabetes, with specific focus on T cells and the T cell receptor (TCR) role in autoimmune disease development. Self-reactive, pancreatic islet antigen specific T cells drive diabetes development; however, the T cell population that infiltrates the pancreas is heterogeneous in phenotype, function, antigen specificity and TCR affinity. The relative contribution of these parameters to disease development and how the T cell population evolves during chronic autoimmunity are mostly unclear. Current projects are focused on autoimmune T cell development and how T cell receptor affinity controls activation of tolerogenic and regulatory pathways that restrain autoimmune activation.

Drs. Maria and Matthew Bettini run a collaborative research group.  See information about each investigators' research work below:

Matthew Bettini, Ph.D.

My research interests are in pursuing how both central and peripheral tolerance mechanisms are crucial in preventing the onset of autoimmunity. View Dr. Matthew Bettini's Research.

Maria Bettini, Ph.D.

My research interests are in the area of autoimmune diabetes, with specific focus on T cells and the T cell receptor (TCR) role in autoimmune disease development. View Dr. Maria Bettini's Research.