The primary function of the Mouse MRI Core facility is to provide high-resolution imaging and spectroscopy to assist Diabetes Research Center members in their research objectives. To achieve this goal, we will review projects and advise investigators which MRI methods would be most appropriate for their projects. Investigators will then be directed to a high-throughput 7.0T Bruker PharmaScan MRI imaging system, purchased by Baylor College of Medicine in June 2004 as part of the Mouse Phenotyping Core. For research projects requiring a higher field system, we will provide access to a 9.4T Bruker Avance MRI imaging system in Dr. Pautler’s lab.
The DRC Mouse MRI Core provides high resolution anatomical and functional information in mouse models of diabetes. Imaging paradigms include T1 and T2 measurements, diffusion tensor imaging (DTI), diffusion weighted imaging (DWI), perfusion imaging, MEMRI axonal transport measurements, anatomical scanning, cardiac imaging, fat assessment and magnetization transfer contrast (MTC). Soon, 1H spectroscopy will be offered.
The chargeback for the 7.0T is currently $100 per hour. The chargeback for the 9.4T magnet is pending.