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Paul Pfaffinger Lab

Publications

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Jerng HH, Pfaffinger PJ. Modulatory mechanisms and multiple functions of somatodendritic A-type K (+) channel auxiliary subunits. Front Cell Neurosci. 2014; 8:82. PMID: 24723849; PMCID: PMC3973911. PubMed

Jerng HH, Pfaffinger PJ. S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation. PLoS One. 2014; 9(3):e93315. PMID: 24675763; PMCID: PMC3968176. PubMed

Pfaffinger PJ. A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation. PLoS One. 2013; 8(11):e79891. PMID: 24236164; PMCID: PMC3827413. PubMed

Kunjilwar K, Qian Y, Pfaffinger PJ. Functional stoichiometry underlying KChIP regulation of Kv4.2 functional expression. J Neurochem. 2013 Aug; 126(4):462-72. PMID: 23692269; PMCID: PMC3737270. PubMed

Prince A, Pfaffinger PJ. Conserved N-terminal negative charges support optimally efficient N-type inactivation of Kv1 channels. PLoS One. 2013; 8(4):e62695. PMID: 23638135; PMCID: PMC3634772. PubMed

Nadin BM, Pfaffinger PJ. A new TASK for Dipeptidyl Peptidase-like Protein 6. PLoS One. 2013; 8(4):e60831. PMID: 23593319; PMCID: PMC3621905. PubMed

Jerng HH, Pfaffinger PJ. Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells. PLoS One. 2012; 7(6):e38205. PMID: 22675523; PMCID: PMC3366920. PubMed

Nadin BM, Pfaffinger PJ. Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells. J Neurosci. 2010 Jun 23; 30(25):8551-65. PMID: 20573902; PMCID: PMC2916862. PubMed

Jerng HH, Dougherty K, Covarrubias M, Pfaffinger PJ. A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism. Channels (Austin). 2009 Nov; 3(6):448-61. PMID: 19901547; PMCID: PMC3607289. PubMed

Prince-Carter A, Pfaffinger PJ. Multiple intermediate states precede pore block during N-type inactivation of a voltage-gated potassium channel. J Gen Physiol. 2009 Jul; 134(1):15-34. PMID: 19528261; PMCID: PMC2712980. PubMed

Jerng HH, Pfaffinger PJ. Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating. J Biol Chem. 2008 Dec 19; 283(51):36046-59. PMID: 18957440; PMCID: PMC2602920. PubMed

Jerng HH, Lauver AD, Pfaffinger PJ. DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels. Mol Cell Neurosci. 2007 Aug; 35(4):604-24. PMID: 17475505; PMCID: PMC3674967. PubMed

Wang G, Strang C, Pfaffinger PJ, Covarrubias M. Zn2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel. J Biol Chem. 2007 May 4; 282(18):13637-47. PMID: 17331952; PMCID: PMC2211274. PubMed

Lauver A, Yuan LL, Jeromin A, Nadin BM, Rodríguez JJ, Davies HA, Stewart MG, Wu GY, Pfaffinger PJ. Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression. J Neurochem. 2006 Nov; 99(4):1207-23. PMID: 17026528; PMCID: PMC3583589. PubMed

Lu CW, Lin JH, Rajawat YS, Jerng H, Rami TG, Sanchez X, DeFreitas G, Carabello B, DeMayo F, Kearney DL, Miller G, Li H, Pfaffinger PJ, Bowles NE, Khoury DS, Towbin JA. Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome. J Med Genet. 2006 Aug; 43(8):653-9. PMID: 16571646; PMCID: PMC2564587. PubMed

Ren Y, Barnwell LF, Alexander JC, Lubin FD, Adelman JP, Pfaffinger PJ, Schrader LA, Anderson AE. Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase. J Biol Chem. 2006 Apr 28; 281(17):11769-79. PMID: 16513649. PubMed

Baker KA, Hilty C, Peti W, Prince A, Pfaffinger PJ, Wider G, Wüthrich K, Choe S. NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain. Biochemistry. 2006 Feb 14; 45(6):1663-72. PMID: 16460013; PMCID: PMC3508000. PubMed

Yuan LL, Chen X, Kunjilwar K, Pfaffinger P, Johnston D. Acceleration of K+ channel inactivation by MEK inhibitor U0126. Am J Physiol Cell Physiol. 2006 Jan; 290(1):C165-71. PMID: 16135544. PubMed

Jerng HH, Kunjilwar K, Pfaffinger PJ. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. J Physiol. 2005 Nov 1; 568(Pt 3):767-88. PMID: 16123112; PMCID: PMC1464192. PubMed

Wang G, Shahidullah M, Rocha CA, Strang C, Pfaffinger PJ, Covarrubias M. Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels. J Gen Physiol. 2005 Jul; 126(1):55-69. PMID: 15955876; PMCID: PMC2266617. PubMed

Jerng HH, Pfaffinger PJ, Covarrubias M. Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci. 2004 Dec; 27(4):343-69. PMID: 15555915. PubMed

Kunjilwar K, Strang C, DeRubeis D, Pfaffinger PJ. KChIP3 rescues the functional expression of Shal channel tetramerization mutants. J Biol Chem. 2004 Dec 24; 279(52):54542-51. PMID: 15485870. PubMed

Jerng HH, Qian Y, Pfaffinger PJ. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J. 2004 Oct; 87(4):2380-96. PMID: 15454437; PMCID: PMC1304660. PubMed

Zhou W, Qian Y, Kunjilwar K, Pfaffinger PJ, Choe S. Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. Neuron. 2004 Feb 19; 41(4):573-86. PMID: 14980206. PubMed

Jeromin A, Yuan LL, Frick A, Pfaffinger P, Johnston D. A modified Sindbis vector for prolonged gene expression in neurons. J Neurophysiol. 2003 Oct; 90(4):2741-5. PMID: 12853440. PubMed

Nanao MH, Zhou W, Pfaffinger PJ, Choe S. Determining the basis of channel-tetramerization specificity by x-ray crystallography and a sequence-comparison algorithm: Family Values (FamVal). Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8670-5. PMID: 12835418; PMCID: PMC166370. PubMed

Strang C, Kunjilwar K, DeRubeis D, Peterson D, Pfaffinger PJ. The role of Zn2+ in Shal voltage-gated potassium channel formation. J Biol Chem. 2003 Aug 15; 278(33):31361-71. PMID: 12754210. PubMed

Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD. PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci. 2002 Dec 1; 22(23):10123-33. PMID: 12451113. PubMed

Jahng AW, Strang C, Kaiser D, Pollard T, Pfaffinger P, Choe S. Zinc mediates assembly of the T1 domain of the voltage-gated K channel 4.2. J Biol Chem. 2002 Dec 6; 277(49):47885-90. PMID: 12372826. PubMed

Choe S, Cushman S, Baker KA, Pfaffinger P. Excitability is mediated by the T1 domain of the voltage-gated potassium channel. Novartis Found Symp. 2002; 245:169-75; discussion 175-7, 261-4. PMID: 12027006. PubMed

Strang C, Cushman SJ, DeRubeis D, Peterson D, Pfaffinger PJ. A central role for the T1 domain in voltage-gated potassium channel formation and function. J Biol Chem. 2001 Jul 27; 276(30):28493-502. PMID: 11312262. PubMed

Adams JP, Anderson AE, Varga AW, Dineley KT, Cook RG, Pfaffinger PJ, Sweatt JD. The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK. J Neurochem. 2000 Dec; 75(6):2277-87. PMID: 11080179. PubMed

Cushman SJ, Nanao MH, Jahng AW, DeRubeis D, Choe S, Pfaffinger PJ. Voltage dependent activation of potassium channels is coupled to T1 domain structure. Nat Struct Biol. 2000 May; 7(5):403-7. PMID: 10802739. PubMed

Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, Sweatt JD. Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem. 2000 Feb 25; 275(8):5337-46. PMID: 10681507. PubMed

Choe S, Kreusch A, Pfaffinger PJ. Towards the three-dimensional structure of voltage-gated potassium channels. Trends Biochem Sci. 1999 Sep; 24(9):345-9. PMID: 10470033. PubMed

Sutherland ML, Williams SH, Abedi R, Overbeek PA, Pfaffinger PJ, Noebels JL. Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):2451-5. PMID: 10051663; PMCID: PMC26805. PubMed

Bixby KA, Nanao MH, Shen NV, Kreusch A, Bellamy H, Pfaffinger PJ, Choe S. Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels. Nat Struct Biol. 1999 Jan; 6(1):38-43. PMID: 9886290. PubMed

Kreusch A, Pfaffinger PJ, Stevens CF, Choe S. Crystal structure of the tetramerization domain of the Shaker potassium channel. Nature. 1998 Apr 30; 392(6679):945-8. PMID: 9582078. PubMed

Pfaffinger PJ, DeRubeis D. Shaker K+ channel T1 domain self-tetramerizes to a stable structure. J Biol Chem. 1995 Dec 1; 270(48):28595-600. PMID: 7499375. PubMed

Shen NV, Pfaffinger PJ. Molecular recognition and assembly sequences involved in the subfamily-specific assembly of voltage-gated K+ channel subunit proteins. Neuron. 1995 Mar; 14(3):625-33. PMID: 7695909. PubMed

Shen NV, Chen X, Boyer MM, Pfaffinger PJ. Deletion analysis of K+ channel assembly. Neuron. 1993 Jul; 11(1):67-76. PMID: 8338669. PubMed

Furukawa Y, Kandel ER, Pfaffinger P. Three types of early transient potassium currents in Aplysia neurons. J Neurosci. 1992 Mar; 12(3):989-1000. PMID: 1545247. PubMed

Kaang BK, Pfaffinger PJ, Grant SG, Kandel ER, Furukawa Y. Overexpression of an Aplysia shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons. Proc Natl Acad Sci U S A. 1992 Feb 1; 89(3):1133-7. PMID: 1310540; PMCID: PMC48400. PubMed

Pfaffinger PJ, Furukawa Y, Zhao B, Dugan D, Kandel ER. Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents. J Neurosci. 1991 Apr; 11(4):918-27. PMID: 2010814. PubMed

Bosma MM, Bernheim L, Leibowitz MD, Pfaffinger PJ, Hille B. Modulation of M current in frog sympathetic ganglion cells. Soc Gen Physiol Ser. 1990; 45:43-59. PMID: 2165636. PubMed

Pfaffinger P. Muscarine and t-LHRH suppress M-current by activating an IAP-insensitive G-protein. J Neurosci. 1988 Sep; 8(9):3343-53. PMID: 3139847. PubMed

Pfaffinger PJ, Leibowitz MD, Subers EM, Nathanson NM, Almers W, Hille B. Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression. Neuron. 1988 Aug; 1(6):477-84. PMID: 2483099. PubMed