Karl-Dimiter Bissig Lab

Publications

Master
Content

A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.
Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD.
Nat Commun. 2017 Jun 28;8(1):39. doi: 10.1038/s41467-017-00049-x

CRISPR/Cas9: at the cutting edge of hepatology.
Pankowicz FP, Jarrett KE, Lagor WR, Bissig KD.
Gut. 2017 Jul;66(7):1329-1340. doi: 10.1136/gutjnl-2016-313565. Epub 2017 May 9. Review.
PMID:28487442

Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia.
Pankowicz FP, Barzi M, Legras X, Hubert L, Mi T, Tomolonis JA, Ravishankar M, Sun Q, Yang D, Borowiak M, Sumazin P, Elsea SH, Bissig-Choisat B, Bissig KD.
Nat Commun. 2016 Aug 30;7:12642. doi: 10.1038/ncomms12642.

Liver is liver and blood is blood, and finally the twain have met.
Bissig KD, Paust S, Barzi M.
J Hepatol. 2016 May 21. pii: S0168-8278(16)30204-5. doi: 10.1016/j.jhep.2016.05.018. [Epub ahead of print] No abstract available.
PMID: 27221221

Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Huang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, López-Terrada D, Bissig KD.
J Hepatol. 2016 Apr 23. pii: S0168-8278(16)30140-4. doi: 10.1016/j.jhep.2016.04.009. [Epub ahead of print]
PMID: 27117591

In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides.
Billioud G, Kruse RL, Carrillo M, Whitten-Bauer C, Gao D, Kim A, Chen L, McCaleb ML, Crosby JR, Hamatake R, Hong Z, Garaigorta U, Swayze E, Bissig KD, Wieland S.
J Hepatol. 2016 Apr;64(4):781-9. doi: 10.1016/j.jhep.2015.11.032. Epub 2015 Nov 30.
PMID: 26658683

Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice.
Shih YM, Sun CP, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MH.
Sci Rep. 2015 Oct 20;5:15259. doi: 10.1038/srep15259.
PMID: 26482836

Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.
Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Kettlun Leyton C, Leung HC, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD.
Nat Commun. 2015 Jun 17;6:7339. doi: 10.1038/ncomms8339.
PMID: 26081744

The camKK2/camKIV relay is an essential regulator of hepatic cancer.
Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York B.
Hepatology. 2015 Aug;62(2):505-20. doi: 10.1002/hep.27832. Epub 2015 May 9.
PMID: 25847065