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Essential involvement of type I interferon in neuroinflammation and synapse loss in Alzheimer's disease
Roy, R.R., Wang, B., Wan, Y.-W., Chiu, G., Cole, A., Yin, Z., Propson, N.E., Jankowsky, J.L., Liu, Z., Lee, V.M.Y, Trojanowski, J., Ginsberg, S.D., Butovsky, O., Zheng, H., and Cao, W.
J. Clin. Invest. (in press)


Cross-species genetic screens identify kinase targets for APP reduction in Alzheimer's disease
Huichalaf, C.H., Al-Ramahi, I.*, Park, K.W.*, Grunke, S.D., Lu, N., de Haro, M., El-Zein, K., Gallego-Flores, T., Perez, A.M., Jung, S.Y., Botas, J., Zoghbi, H.Y., and Jankowsky, J.L.
Hum. Mol. Genet. 28:2014-2029 (2019)

Brain-wide distribution of reporter expression in five transgenic tetracycline-transactivator mouse lines
Lillehaug, S., Yetman, M.J., Puchades, M.A., Checinska, M.M, Kleven, H., Jankowsky, J.L., Bjaalie, J.G., and Leergaard, T.B.
Sci. Data 6:190028 (2019)


Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice
Chiang, A.C-A., Fowler, S.W., Savjani, R.R., Hilsenbeck, S.G., Wallace, C.E., Cirrito, J.R., Das, P. and Jankowsky, J.L.
J. Exp. Med. 215:1349-1364 (2018)

Discrete pools of oligomeric amyloid-β track with spatial learning deficits in a mouse model of Alzheimer's amyloidosis
Chiang, A.C.A.*, Fowler, S.W.*, Reddy, R., Pletnikova, O., Troncoso, J.C., Sherman, M.A., Lesne, S., and Jankowsky, J.L.
Am J. Pathol. 188:739-756 (2018)


Practical considerations for choosing a mouse model of Alzheimer's disease
Jankowsky, J.L. and Zheng, J.
Mol. Neurodegen. 12:89 (2017)

Combination of Aβ suppression and innate immune activation in the brain significantly attenuates amyloid plaque deposition
Verbeeck, C.*, Carrano, A.*, Chakrabarty, P., Jankowsky, J.L., and Das, P.
Am J. Pathol. 187:2886-2894 (2017)


Neuronal overexpression of human VAPB slows motor impairment and neuromuscular denervation in a mouse model of ALS
Kim, J-Y., Jang, A., Reddy, R., Yoon, W.H., and Jankowsky, J.L.
Hum. Mol. Genet. 25:4661-4673 (2016)

Impaired recall of positional memory following chemogenetic disruption of place field stability
Zhao, R., Grunke, S.D., Keralapurath, M.M., Yetman, M.J., Lam, A., Lee, T.C., Jiang, Y., Swing, D.A., Tessarollo, L., Ji, D., and Jankowsky, J.L.
Cell Repts. 16:1-12 (2016)

Amyloid-β plaques disrupt axon initial segments
Marin, M.A., Ziburkus, J., Jankowsky, J.L., and Rasband, M.N.
Exp. Neurol. 281:93-98 (2016)

Humanized tau mice with regionalized amyloid exhibit behavioral deficits but no pathological interaction
Yetman, M.J., Fowler, S.W., and Jankowsky, J.L.
PLoS ONE 11: e0153724. doi:10.1371/journal.pone.0153724 (2016)

Astrocyte-microglia crosstalk through complement activation modulates amyloid pathology in mouse models of Alzheimer's disease
Lian, H. Litvinchuk, A., Chiang, A.C.-A., Aithmitti, N., Jankowsky, J.L., and Zheng, H.
J. Neurosci. 36:577-589 (2016)

Widespread neuronal transduction of the rodent CNS via intraventricular viral injection of the neonate
Kim, J.-Y.*, Grunke, S.D.*, and Jankowsky, J.L.
Methods Mol. Biol. 1382:239-250 (2016)

Transgene expression in the neuropsin-tTA driver line is not inherently restricted to the entorhinal cortex
Yetman, M.J., Lillehaug, S., Bjaalie, J.G., Leergaard, T.B., and Jankowsky, J.L.
Brain Struct. Funct. 221:2231-2249 (2016)


Quaternary structure defines a large class of amyloid-β oligomers neutralized by sequestration
Liu, P., Reed, M.N., Kotilinek, L.A., Grant, M.K.O., Forster, C.L., Qiang, W., Shapiro, S.L., Reichl, J.H., Chiang, A.C.A., Jankowsky, J.L., Wilmot, C.M., Cleary, J.P., Zahs, K.R., and Ashe, K.H.
Cell Repts. 11:1760-1771 (2015)

Wild type microglia do not arrest pathology in mouse models of Rett syndrome
Wang, J., Wegener, J.E., Huang, T.-W., Sripathy, S., Jesus-Cortes, H.D., Xu, P., Tran, S., Knobbe, W., Britt, J., Starwalt, R., McDaniel, L., Ward, C., Parra, D., Newcomb, B., Lao, U., Leko, V., Flowers, D., Cullen, S., Yetman, M., Jorstad, N., Yang, Y., Glaskova, L., Vigneau, S., Kozlitina, J., Reichardt, S.D., Reichardt, H.M., Gartner, J., Bartolomei, M.S., Fang, M., Loeb, K., Keene, C.D., Bernstein, I., Jankowsky, J.L., Goodell, M., Brat, D.J., Huppke, P., Neul, J.L., Bedalov, A., and Pieper, A.A.,
Nature 521:E1-4 (2015)

NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s disease
Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A.C-A., Fowler, S.W., Shim, D.J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J.L., Lu, H-C., and Zheng, H.
Neuron 85:1-15 (2015).


Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction
Kim, J.-Y.*, Grunke, S.D.*, Levites, Y., Golde, T.E., and Jankowsky, J.L.
JoVE, 91: e51863, doi:10.3791/51863 (2014)

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer’s disease
Fowler, S.W.*, Chiang, A. C-A.*, Savjani, R.R., Larson, M.E., Schuler, D.R., Cirrito, J.R., Lesne, S., and Jankowsky, J.L.
J. Neurosci. 34:7871-7885 (2014)

Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer’s disease
Zhao, R., Fowler, S.W., Chiang, A.C.-A., Ji, D.*, and Jankowsky, J.L.*
Hippocampus 522:1191-1208 (2014)

Genetic suppression of transgenic APP rescues hypersynchronous network activity in a mouse model of AD
Born, H.A., Kim, J.-Y., Das, P., Dabaghian, Y., Guo, Q., Yoo, J.W., Schuler, D.R., Cirrito, J.R., Zheng, H., Golde, T.E., Noebels, J.L., and Jankowsky, J.L.
J. Neurosci. 34:3826-3840 (2014)

Specificity and efficiency of reporter expression in adult neural progenitors varies substantially among nestin-CreERT2 lines
Sun, M.-Y., Yetman, M.J., Lee, T.-C., Chin, Y., and Jankowsky, J.L.
J. Comp. Neurol. 522:1191-1208 (2014)

Computed tomography for detection of vascular leak in a mouse model of amyloid neuropathology
Tanifum, E.A., Starosolski, Z.A., Ghaghada, K., Fowler, S.W., Jankowsky, J.L., and Annapragada, A.V.
J. Cereb. Blood Flow Metab. 34:1646-1654 (2014)


Wild-type neural progenitors divide and differentiate normally in an amyloid rich environment
Yetman, M.J. and Jankowsky, J.L.
J. Neurosci. 33:17335-17341 (2013)

Viral transduction of the neonatal delivers controllable genetic mosaicism for visualizing and manipulating neuronal circuits in vivo
Kim, J.-Y., Ash, R., Ceballos-Diaz, C., Levites, Y., Golde, T.E., Smirnakis, S.M., and Jankowsky, J.L.
Eur J. Neurosci. 37:1203-1220 (2013)

Capsid serotype and timing of injection determines AAV transduction in the neonatal mouse brain
Chakrabarty, P., Rosario, A., Cruz, P., Siemienski, Z., Ceballos-Diaz, C., Crosby, K., Jansen, K., Borchelt, D.R., Kim, J.-Y., Jankowsky, J.L., Golde, T.E., and Levites, Y.,
PLoS ONE 8:e67680 (2013)

Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator
Han, H.J., Allen, C.A., Buchovecky, C.M., Yetman, M.J., Born, H.A., Marin, M.A. Rodgers, S.P., Song, B.J., Lu, H.-C., Probst, F.J., and Jankowsky, J.L.
J Neurosci. 32:10574-10586 (2012)

Transgenic APP expression during postnatal development causes persistent motor hyperactivity in the adult
Rodgers, S.P., Born, H.A., Das, P, and Jankowsky, J.L.
Molec. Neurodegen. 7:28 (2012)

Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington’s disease transgenic mouse
Cowin, R.-M., Roscic, A., Bui, N., Graham, D., Paganetti, P., Jankowsky, J.L., Weiss, A., and Paylor, R.
Behav. Brain Res. 229:308-319 (2012)

Robust amyloid clearance in a mouse model of AD provides novel insights into the mechanism of Aβ immunotherapy
Wang, A., Das, P., Switzer, R.C., Golde, T.E., and Jankowsky, J.L.
J Neurosci. 31:4124-4136 (2011)


Automated volumetric MR analyses identify remote sites of structural atrophy prior to amyloid formation in a mouse model of Alzheimer’s disease
Badea, A., Johnson, G.A., and Jankowsky, J.L.
NeuroImage 50:416-427 (2009)

Alzheimer’s-type amyloidosis in mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis
Verret L.*, Jankowsky J.L.*, Xu G., Borchelt D.R., and Rampon C.
J. Neurosci. 27:6771-6780 (2007)

Rodent Aß modulates the solubility and distribution of human Aß amyloid in transgenic mice
Jankowsky J.L., Younkin L.H., Gonzales V., Fadale D.J., Slunt H.H., Lester H.A., Younkin S.G., and Borchelt D.R.
J. Biol. Chem. 282:22707-22720 (2007)

Persistent amyloidosis following suppression of Aß production in a transgenic model of Alzheimer’s disease.
Jankowsky J.L., Slunt, H.H., Gonzales, V., Savonenko, A.V., Wen, J., Jenkins, N.A., Copeland, N.G., Younkin, L.H., Lester, H.A., Younkin, S.G., and Borchelt, D.R.
PLoS Medicine 2:e355 (2005)

Environmental enrichment ameliorates cognitive decline in a mouse model of Alzheimer’s disease
Jankowsky J.L., Melnikova T., Fadale, D.J., Xu, G.M., Slunt, H.H., Gonzales, V., Younkin, L.H., Younkin, S.G., Borchelt, D.R., and Savonenko, A.V.
J. Neurosci. 25:5217-5224 (2005)


Mutant presenilins specifically elevate the levels of the 42-residue ß-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ-secretase
Jankowsky J.L., Fadale, D.J., Anderson, J., Xu, G., Gonzales, V., Jenkins, N.A., Copeland, N.G., Lee, M.K., Younkin, L.H., Wagner, S.L., Younkin, S.G., and Borchelt, D.R.
Hum. Mol Genet. 13:159-170 (2004)

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
Jankowsky, J.L., Slunt, H.H., Gonzales, V., Jenkins, N.A., Copeland, N.G., and Borchelt, D.R.
Neurobiol. Aging 25:885-892 (2004)

Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer’s disease.
Jankowsky, J.L., Xu, G., Gonzales, V., Fromholt, D., and Borchelt, D.R.
J. Neuropathol. Exp. Neurol. 62:1220-1227 (2003)

Transgenic mouse models of neurodegenerative disease: Opportunities for therapeutic development
Jankowsky, J.L., Savonenko, A., Schilling, G., Wang, J., Xu, G., and Borchelt, D.R. (2002)
Curr. Neurol. Neurosci. Repts. 2: 457-464 [review] (2002)

Coexpression of multiple transgenes in the mouse CNS: a comparison of strategies
Jankowsky, J.L., Slunt, H.H., Ratovitski, T., Jenkins, N.A., Copeland, N.G., and Borchelt, D.R.
Biomol. Eng. 17: 157-165 (2001)

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice
Lesuisse, C. Xu, G., Anderson, J., Wong, M., Jankowsky, J., Holtz, G., Gonzalez, V., Wong, P.C.Y., Price, D.L., Tang, F., Wagner, S., and Borchelt, D.R.
Hum. Mol. Genet. 10: 2525-2537 (2001)

The role of cytokines and growth factors in seizure and its sequelae
Jankowsky, J.L., and Patterson, P.H.
Prog. Neurobiol. 63: 125-149 [review] (2001)

Cytokine responses to LTP induction in the rat hippocampus: A comparison of in vitro and in vivo techniques
Jankowsky, J.L., Derrick, B.E., and Patterson, P.H.
Learn. & Mem. 7: 400-412 (2000)

Cytokine and growth factor involvement in long-term potentiation
Jankowsky, J.L., and Patterson, P.H.
Mol. Cell. Neurosci., 14:529-543 [review] (2000)

Differential regulation of cytokine expression following pilocarpine-induced seizure
Jankowsky, J.L., and Patterson, P.H.
Exp. Neurol. 159: 333-346 (1999)

Media Component
Co-injection of AAV expressing either YFP or tdTomato into the neonatal mouse brain produces mosaic expression in the adult.

Mosaic Expression of Fluorescent Proteins via Intraventricular Viral Injection


Postdoctoral fellow Ji-Yoen Kim optimized dual AAV injection into the neonatal mouse brain to produce mosaic expression in the adult.