We are privileged to work on projects with many outstanding clinicians and scientists, including:
Jan and Dan Duncan Neurological Research Institute and Baylor College of Medicine
The Baylor Parkinson's Disease Center and Movement Disorders Clinic
Baylor Alzheimer's Disease and Memory Disorders Center
Brigham and Women's Hospital and Harvard Medical School
Rush Alzheimer's Disease Center
Cohorts for Heart and Aging Research in Genomic Epidemiology
Sudha Seshadri, M.D. (Boston University)
Lenore Launer, Ph.D. (National Institute on Aging)
Myriam Fornage, Ph.D. (University of Texas Houston)
M. Arfan Ikram, M.D. (Erasmus Medical Center)
Joshua Bis, Ph.D. (University of Washington) University of Maryland
Parkinson's Disease Center
Our Research Approaches
Our overall strategy incorporates two complementary approaches:
We conduct human genetic analyses based on clinical and neuropathologic endophenotypes, promoting both functional dissection of emerging disease susceptibility loci and novel gene discovery.
Genetic models of disease in the fruit fly, Drosophila melanogaster, are leveraged for rapid functional screening of human susceptibility loci, allowing efficient identification of responsible genes and characterization of mechanisms in disease pathogenesis.
Projects are initiated in both the human or model organism context, and reciprocal, cross-species investigation promotes efficient progress toward our goals. Discovery, validation, and functional characterization of the gene networks responsible for AD and PD susceptibility will advance our understanding of the neurobiology of cognition and motor control, reveal the genetic architecture of healthy and pathologic brain aging, and ultimately, promote improved therapies.