Our Research Approaches
Our approaches are cutting-edge and include unique in vitro and in vivo models of BMBC, lentiviral delivery targeting heparanase with microRNA, small molecule HPSE inhibitors, and innovative study designs of the biology of CTCs. They emphasize the strong translational component of our programs which hold a great potential for new understandings of BMBC onset and regulation. They will provide the essential groundwork to introduce heparanase-based therapies in patients with brain metastases in general, breast cancer brain metastasis in particular. We are fully dedicated to this goal.