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Cell and Gene Therapy for Musculoskeletal Disorders

Role of Peripheral Nerve Injury and Blood-nerve Barrier in HO

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Our lab’s previous studies have demonstrated that osteogenic progenitors that contribute to HO are housed in the endoneurium in a mouse model. The results of our studies in larger animals such as rats have indicated that a similar model to induce bone with BMP2-producing cells does not produce the same results.

We have hypothesized that this could be due to the more sophisticated peripheral nervous system in higher order species, which possess multi-fascicled nerves and a complex blood-nerve barrier.

We are currently testing whether a mechanical or chemical opening of this barrier contributes to the formation of bone in BMP2-induced neurogenic HO.

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Contact Us

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Alan R. Davis
ardavis@bcm.edu
(713) 798-1237

Elizabeth A. Olmsted-Davis
edavis@bcm.edu
(713) 798-1253

Lab Phone: (713) 798-1238
Lab Fax: (713) 798-1230