Key Research Questions
- What are the cellular and molecular mechanisms by which cancer-induced inflammation leads to immunosuppression and cancer immune escape?
- What is the impact of standard therapies – such as surgery, chemotherapy, and radiotherapy – on anti-tumor immunity and response to immunotherapies?
- How can we use information about changes in the genomic, metabolic, and immunological profile of patients and their tumors to select the therapies most effective for their cancer?
To answer these questions we perform studies in mouse- and chick egg-based model tumor systems; human cell and cell-line culture experiments; studies of patient samples collected before and after treatment; and clinical trials with new immune-based therapies.