Plants experience a dynamic environment where numerous stress conditions must be mitigated simultaneously. For example, flooding induces the stresses of limited oxygen, changes in temperature, light, osmotic and oxidative conditions. Anoxia is a consequence of waterlogging and submergence of plants. This was seen in Houston in the fall of 2018, when the city received over 50 inches of rain in a three-day period. To ensure survival and limit post-anoxic injury plants must carefully regulate the flow of the little energy produced under stress conditions to essential processes. The transcriptional networks that control gene regulation during oxygen deprivation have been well studied, but the mechanism remain unknown. Our lab has discovered that mutations in the Arabidopsis vacuolar cation/proton exchanger 1 (CAX1) cause dramatic tolerance to anoxic conditions. This robust phenotype was unexpected, and highlights the limitations of transcriptional profiling, because CAX1 gene expression remains unchanged during hypoxia. A series of genetic, imaging and physiological experiments are being undertaken to characterize the role of CAXs in post-anoxic injury. In the future, engineering-impaired CAX expression could circumvent adverse effects of anoxic conditions that impair production agriculture.