Selective Neuronal Silencing to Study Cognitive Decline in Alzheimer's Disease
This study will examine the contribution of specific neuronal circuits in the progressive cognitive decline of Alzheimer's disease. As part of this project, we will create a new transgenic mouse in which genetically-defined neuronal populations can be selectively silenced through activation of an exogenously-expressed chloride channel. The new mouse will be broadly applicable to the study of neurodevelopmental and neurodegenerative diseases as a means to explore the behavioral consequences of pathological circuit dysfunction.
Relevance of the project to IDDRC mission:
This project will construct and characterize a mouse model in which any genetically-defined neuronal population can be acutely silenced at will. This model will allow us to more precisely identify which neuronal circuits contribute to particular behavioral changes in disease, either due to mis-wiring of the brain during development or to degeneration through disease.