Dopamine Signaling Dysfunction Precedes and Predicts Neuron Loss in an Animal Model of Parkinson's Disease
We will study the relationship between the decline in Nurr1 expression and dopamine neuron dysfunction related to Parkinson's Disease.
Relevance of the project to IDDRC mission:
The project examines dopamine signaling both in vivo and in vitro from control mice and mice with a defect in the transcription factor, Nurr1. This mouse model is aimed to become a basis for judging dopamine dysfunction that develops with age during the progression to Parkinson's disease. Such patients suffer mainly from a movement disorder, but they also suffer from cognitive and memory problems, which also is an area of interest to us. Therefore, .the work should provide a basis for understanding synaptic events that underlie the behavior and symptoms that also are indicative of mental retardation.