The main objective of the Neuropathology core is to provide BCM-IDDRC investigators with facilities and expertise for the characterization of tissues from human samples and animal models. Services include histology, histochemistry, immunohistochemistry, and interpretation of anatomical and histopathological findings. The Neuropathologist and Core technicians are available to the BCM-IDDRC investigators and their trainees for instruction in all of the techniques, and in the interpretation of the studies. In some cases the trainee will, under this supervision, develop the techniques in their own laboratory.
The Baylor IDDRC consists of researchers working within various areas of expertise, in which human and animal tissues are investigated in order to characterize molecular, chemical and morphologic markers. The morphologic studies include the demonstration of gene products within cells, identification of specific cell types, histochemical identification of enzyme activity, ultrastructural characterization of cell organelles, confirmation of the presence of pathognomonic lesions in human and animal study subjects, and the identification of the presence or absence of structural integrity of the nervous system in transgenic and mutant animal models of human disease. The Neuropathology core provides support for these necessary studies: careful neuropathologic and immuno-localization analyses IDD and the function of neuronal and developmental genes.
Director: Roy Sillitoe, Ph.D.