Core E: Study Design and Clinical Specimen Core Services
David Graham, M.D., Director
Hashem B. El-Serag, M.D., M.P.H., Co Director
Claudia A. Kozinetz, Ph.D., M.P.H., Co-Director
The Study Design and Clinical Research Core aims to promote the use of appropriate study design, statistical analyses, and interpretation for clinical and basic science investigators, to assist these investigators in acquiring clinical specimens to facilitate their research, as well as to assist investigators in designing and performing translational and outcomes research. The primary goals of this Core include establishing procedures and providing assistance with:
- Study design, including study population identification, sample size and power estimates;
- Specimen collection, including links to local, regional and national tissue banks;
- Outcomes research, including clinical epidemiology, pharmacoepidemiology and health economics;
- Data management, including design, development and maintenance of databases;
- Biostatistical analysis, including plans for IRB applications, pilot and feasibility grants, NIH proposals and manuscripts.
This Core is located at the Houston VA Medical Center and the Department of Pediatrics, Baylor College of Medicine. The services provided by the Core are available to clinical, outcomes, basic science and translational investigators. The Core has also established a formal mechanism and specific procedures that can assist investigators with access to clinical specimens. To accomplish this, the Core Director is assisted by specific collaborating investigators in adult and pediatric gastroenterology and pediatric surgery who can identify appropriate sources for the specimens. The availability of this Core greatly increases the use of study design and biostatistical expertise by clinical, outcomes, basic and translational scientists, and can markedly enhance the ability of scientists to conduct translational research projects that traverse the gap from bench to populations..
Please credit the "NIH/National Institute of Diabetes and Digestive and Kidney Disease, Center Grant P30 DK56338" in publications resulting from core usage or pilot funds.