Core B: Cellular and Molecular Morphology Core
J. Finegold, M.D., Director
Sridevi Devaraj, Ph.D., Associate Director
Michael Mancini, Ph.D., Associate-Director
Cecilia Ljungberg, Ph.D., Associate-Director
The Morphology Core provides expertise, equipment and procedures relevant to GI research, makes available its specialized laboratory facilities to GI researchers, and aids the development of new tests that may be useful in clinical and basic research. Major core services include histology, immunohistochemistry, in-situ hybridization, frozen sections for enzyme histochemistry, immunofluorescent antibody studies, DNA and RNA extraction, transmission, scanning, and immunoelectron microscopy, quantitative morphometric analysis and laser capture dissection for molecular genetic analyses.
The Core also provides consultation and training in the proper collection, fixation, storage and handling of human and animal tissues, as well as training and technical advice to researchers interested in developing sophisticated procedures for their GI-related research projects. In coordination with the Study Design and Clinical Research Core and the Integrative Biology, a bank of human and mouse gastrointestinal and liver tissue, both normal and diseased, has been created in order to make these valuable samples available to center researchers for specific projects, as controls for their studies, and to test new reagents and methods. A major benefit of the Core is to utilize information and expertise gained from diverse projects in individual laboratories to enhance the productivity of all DDC researchers.
Please credit the "NIH/National Institute of Diabetes and Digestive and Kidney Disease, Center Grant P30 DK56338" in publications resulting from core usage or pilot funds.