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CNRC - Xu Lab

Houston, Texas

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CNRC - Xu Lab
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Postdocs and Visiting Scholars

Hui Mei, Ph.D.Chunmei Wang, Ph.D.

Education

BS Nanjing Agriculture University, 2004
Ph.D. Institute of Biochemistry and Cell Biology, SIBS, CAS., 2011

Publications

  1. Wang CM, Huang CY, Gu YH, Zhou YC, Zhu ZM and Zhang YL. (2010) Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system. Glycobiology 21, p225.
  2. Zhan XN, Wang CM, Liu AH , Liu Q, Zhang YL. Region-specific localization of IMDS-60 protein in mouse epididymis and its relationship with sperm maturation. Acta Biochimica et Biophysica Sinica. In publishing.
  3. Shi J, Wang DM, Wang CM, Hu Y, Liu AH, Zhang YL, Sun B, Song JG. (2009) Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial-mesenchymal transition. Cancer Res. Sep 15;69 (18):7180-7. Epub 2009 Sep 8.

Project Interest & Description

To determine if ERalpha in developing brains is required to “program” body weight balance later in life.

Fun Fact

I abhor strong smells and detest unprofessionalism.


Jay Morris, Ph.D.Chunling Yan M.D., Ph.D.

Education

M.D. Binzhou Medical College, China, 1996
MA Physiology, Medical School of Qingdao University, China, 2000
Ph.D. Marine Biology, The Ocean University of China, 2006

Publications

  1. Chun-Ling Yan, Hong-bin Wang, Chun-bo Wang, Wan-shunLiu (2012). The effects of water soluble chitosan on the fracture healing in New Zealand rabbits. Journal of surgical research. (Manuscripts submitted)
  2. Chun-Ling Yan, Chun-bo Wang, Wan-shunLiu (2010). The effects of water soluble chitosan on the osteoblast-MC3T3-E1 proliferation and differentiation. Chin Mar Drugs .29(3): 8-10.
  3. Junli Ye, Xiangjun Meng(coauthor), Chunling Yan, Chunbo Wang (2010). Effect of Purple Sweet Potato Anthocyanins on β-Amyloid-Mediated PC-12 Cells Death by Inhibition of Oxidative Stress. Neurochemical Research. 35( 3): 357-365.
  4. Chun-Ling Yan, Bo-xiao Ding , Xiao-ming Lan, Shen-bo Guo, Yan-ying Xie, Chun-Bo Wang(2008). The toxicity study on marine low-temperature lysozyme. Food and Chemical Toxicology . 46: 604-609
  5. Hai-ying Chen, Xiao Chu, Chun-ling Yan, Xue-hong Chen, Mi Su, Yue-jun Wang, Chun-bo Wang (2007). polypeptide form chlammy farreri attenuates murine thymocytes damage induced by ultraviolet B. Acta Pharmacologica Sin. 10: 1665-1670.
  6. Chun-Ling Yan, Bing Liu,Wan-shunLiu (2007). Effect of chitooligosaccharides and its derivatives on oral glucose tolerance test and intestinal microecological balance in diabetic rats. World Chiese Journal of Digestology. 15(11): 1202-1207.
  7. Hong-bing Wang Chun-ling Yan, Chun-bo Wang (2007). Synergism of polypeptides fromChlamys farrer on the antitumor effect of cytoxan. Chin Mar Drugs . 26(5):38-40
  8. Chun-Ling Yan, Rou-Yong Yao ,Li-Yan Jing, Yao-Jun Wang, Wan-Shun Liu, Chun-Bo Wang (2006). A polypeptide from Chlamys farreri abolishes UV-induced apoptosis in murine thymocytes in vitro .Journal of photochemistry and photobiology .84(3) 198-196.
  9. Chun-Ling Yan, Wan-shunLiu , Bing Liu (2006). Effects of law-chitosan on blood glucose in diabetic mice. Acta academiae medicine Qingdao Universitatis. 42: 352-353.
  10. Mian-qing Huang, Chun-ling Yan, Mei Dou, Chun-bo Wang (2005). The antioxidative effect of polypeptide from Chlamys farreri (PCF) on HaCaT cells damaged by UVB. Chin Mar Drugs ,24(3)26-28.
  11. Li-hua Fang, Hai-ying Chen, Chun-ling Yan, Chun-bo Wang (2006).The protective effect of PCF against murine thymocytes apoptosis induced by UVB irradiation. Chin Mar Drugs,25(2):29-31.
  12. Chun-ling Yan, Guo-liang Zhang, Song-Mei Zhan , Wan-Shun Liu, Yao-Jun Wang, Chun-Bo Wang (2005). Protective effects of polypeptide from Chlamys farreri on murine thymocytes damaged by ultraviolet ray. Chin Mar Drugs ,24(6):28-31.
  13. Chun-ling Yan, Shou-Biao Wang, Zheng-Rao Jiang, Ming Tang (2002). The effects of motilin in PVN of hypothalamus on the gastric motility. Chinese Journal of Applied Physiology. 18(4): 317-320.

Project Interest & Description

To explore the 5-HT2CR-DA circuit that mediates the anti-binge effects of 5-HT compounds. Also, to understand the roles of central 5-HT in feeding behaviors.


Murli ManoharYan Xia, Ph.D.

Education

BS China Pharmaceutical University, Nanjing, China Degree, 1999
MS Fudan University, Shanghai, China Degree, 2002
Ph.D. University of Texas Medical Branch, Galveston, US Degree, 2009

Publications

Xia Y, Portugal GS, Fakira AK, Melyan Z, Neve R, Lee HT, Russo SJ, Liu J, Morón JA. Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine. J Neurosci. 2011 Nov 9;31(45):16279-91.

Billa SK, Xia Y, Morón JA. Disruption of morphine-conditioned place preference by a δ2-opoid receptor antagonist: study of μ-opioid and δ-opioid receptor expression at the synapse. Eur J Neurosci. 2010 Aug; 32(4): 625-31.

Xia Y, Wang CZ, Liu J, Anastasio NC, Johnson KM. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology. 2010 Feb; 58(2):330-6.

Anastasio NC, Xia Y, O'Connor ZR, Johnson KM. Differential role of NR2A and NR2B N-methyl-d-asparatate receptors in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience, 2009 Nov 10; 163(4):1181-91.

Xia Y, Wang CZ, Liu J, Anastasio NC, Johnson KM. Lithium protection of phencyclidine-induced neurotoxicity in developing brain: the role of phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways. J Pharmacol Exp Ther. 2008 Sep; 326(3):838-48.

Lei G, Xia Y, Johnson KM. The Role of Akt-GSK-3beta Signaling and Synaptic Strength in Phencyclidine-Induced Neurodegeneration. Neuropsychopharmacology. 2008 May;33(6):1343-53

Wang CZ, Yang SF, Xia Y, Johnson KM. Postnatal phencyclidine administration selectively reduces adult cortical parvalbumin-containing interneurons. Neuropsychopharmacology. 2008 Sep; 33(10):2442-55.

Project Interest & Description

My project is try to find out what and how psychological stress during childhood affects blood pressure and glucose metabolism. Specifically, I’m focusing on the potential anti-hypertension effect of estrogen and its receptors in the medial amygdale during psychological stress. In the exciting new avenue of research, we are using the Cre-loxP strategy, combining with photogenetic technology, systemic physiology, and cell-based techniques, to target the interested neuronal circuitry and transmitters to reveal the complex CNS networks that control and blood pressure, body weight homeostasis, and glucose balance.


Hui Mei, Ph.D.Kenji Saito, M.P.E, Ph.D.

Education

BPE Exercise Physiology, Nihon University, Tokyo, Japan, 1995
MPE Exercise Physiology, University of Tsukuba, Tsukuba, Japan, 2001
Ph.D. Neuroscience, the Graduate University for Advanced Studies (SOKENDAI) Kanagawa, Japan, 2011

Publications

  1. Saito, K., Kakizaki, T., Hayashi, R., Nishimaru, H., Furukawa, T., Nakazato, Y., Takamori, S., Ebihara, S., Uematsu, M., Mishina, M., Yanagawa, Y., et al. (2010). The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice. Mol Brain 3, 40.
  2. Wang, Y., Kakizaki, T., Sakagami, H., Saito, K., Ebihara, S., Kato, M., Hirabayashi, M., Saito, Y., Furuya, N., and Yanagawa, Y. (2009). Fluorescent labeling of both GABAergic and glycinergic neurons in vesicular GABA transporter (VGAT)-venus transgenic mouse. Neuroscience 164, 1031-1043.
  3. Fujii, M., Arata, A., Kanbara-Kume, N., Saito, K., Yanagawa, Y., and Obata, K. (2007). Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter. Neuroscience 146, 1044-1052.

Project Interest & Description

Among various aspects of energy homeostasis, my main concern is maintenance of body weight by central regulation of energy expenditure. Specifically, I’m studying how each subpopulation of neurons in hypothalamus regulates various aspects of energy balance. I am also interested in the development of new genetic tools to study neural regulation of energy homeostasis.

Fun Fact

It hasn’t been long since I arrived at Houston and it’s exciting for me to do even small things like shopping and exploring the city. If I have a full day off, I like to stop by the bookstore to find an interesting book to read.


Jay Morris, Ph.D.Xuehong Cao, M.D., Ph.D.

Education

BA Medicine, Anhui Medical University, 2002
MS Neuropharmacology, Tongji Medical University, 2005
MS Electrophysiology, Tongji Medical University, 2008
Research Assistant, University of Texas, MD. Anderson Cancer Center, 2008
Post-doctoral fellow, University of Texas, MD. Anderson Cancer Center, 2012

Publications

  1. Wang W, Cao XH, Liu CJ, Liu LJ. Cannabinoid WIN 55,212-2 inhibits TRPV1 in trigeminal ganglion neurons via PKA and PKC pathways. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2012;33(1):79-85. Epub 2011/05/18.
  2. Li L, Cao XH, Chen SR, Han HD, Lopez-Berestein G, Sood AK, et al. Up-regulation of Cavbeta3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. The Journal of biological chemistry. 2012;287(8):6002-13. Epub 2011/12/22.
  3. Cao XH, Chen SR, Li L, Pan HL. Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons. Journal of neurochemistry. 2012;121(6):944-53. Epub 2012/03/21.
  4. Pan JP, Zhang HQ, Wei W, Guo YF, Na X, Cao XH, Liu LJ. Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats. Brain research. 2011;1412:18-27. Epub 2011/08/02.
  5. Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. The Journal of biological chemistry. 2011;286(38):33190-202. Epub 2011/08/05.
  6. Cao XH, Byun HS, Chen SR, Pan HL. Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons. Journal of neurochemistry. 2011;119(3):594-603. Epub 2011/09/03.
  7. Cao XH, Byun HS, Chen SR, Cai YQ, Pan HL. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. Journal of neurochemistry. 2010;114(5):1460-75. Epub 2010/06/19.
  8. Chen L, Liu CJ, Liu LJ, Cao XH. Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons. Neuroscience research. 2009;64(2):199-207. Epub 2009/05/12.
  9. Cao XH, Cao XS, Xie H, Yang R, Lei G, Li F, Liu LJ. Effects of capsaicin on VGSCs in TRPV1-/- mice. Brain research. 2007;1163:33-43. Epub 2007/07/17.
  10. Cao XH, Ming ZY, Fu H, Pan JP, Liu LJ. Effects of inhibitor of serine/threonine protein phosphatases 1 and 2A on voltage-dependent sodium channels in rat trigeminal ganglion neurons. Chin J Pharmacology toxical. 2005;19(4):248-53.

Book Chapter: “The Goodman and Gilman Manual of Pharmacology and Therapeutics, the Chinese version of 11th edition.” 2009.4. ISBN: 978-7-03-023446-9. One of the compilers/translators.

Fun Fact

I love new trends in fashion, pop-culture, and world news. I also enjoy listening to 80s music (Michael Jackson).


Murli ManoharHongfang Ding, M.D.

Education

BS Clinic Medicine, Tongji Medical University, 1998
MS Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 2003
M.D. Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 2007

Project Interest & Description

My research project is to study the role of CNS 5-HT2cR in energy homeostasis.

Fun Fact

  • I enjoy shopping and spending my time online looking for new things to buy.
  • I also was a doctor in China before coming to the United States of America.
  • My research project motivates me to help save lives.

Hui Mei, Ph.D.Xiaofeng Yan, M.D., Ph.D.

Education

BA Medicine, Tongi Medical College, H.U.S.T, 2001
MS Dermatology, Tongi Medical College, H.U.S.T, 2004
Ph.D. Dermatology, Tongi Medical College, H.U.S.T, 2007
Visiting Scholar, Dermatology, Kyushu University, 2010
Post-doc, Neuroendocrinology, The University of Texas, MD Anderson Cancer Center, 2011

Publications

  1. Zhu L, Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O’Malley BW, Xu Y. Steroid receptor co-activator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 2012 (in press).
  2. Yan XF, Takahara M, Xie LN, et al. Arginine metabolism in soft tissue sarcoma. J Dermatol Sci, 2011; 61(3): 211-215.
  3. Yan XF, Takahara M, Xie LN, et al. Cathepsink expression: a useful marker for the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. Histopathology, 2010; 57(3): 486-488.
  4. Yan XF, Takahara M, Dugu L, et al. Expression of cathepsin K expression in neurofibromatosis 1-associated neurofibromas and cutaneous malignant peripheral nerve sheath tumors. J Dermatol Sci, 2010; 58(3): 227-229.
  5. Yan XF, Takahara M, Xie LN, et al. Stromal expression of cathepsink in squamous cell carcinoma. J Eur Acad Dermatol Venereol, 2010; 25(3): 362-365.
  6. Xie LN, Hayashida S, Yan XF, et al. Over-expression of stromal cathepsin K correlates with progression of extrammary Paget’s disease. Eur J Dermatol, 2010; 20(3): 415-416.
  7. Tashiro A, Takeuchi S, Nakahara T, Oba J, Tsujita J, Fukushi J, Kiryu H, Oda Y, Xie LN, Yan XF, et al. Aberrant expression of CD10 in ground-glass-like multinucleated giant cells of multicentric reticulohistiocytosis. J Dermatol, 2010; 37(11): 995-7.
  8. Liu DX, Cao F, Yan XF, et al. Retinoic acid syndrome in a patient with psoriasis. Eur J Dermatol, 2009; 19(6): 632-4. (Corresponding author)
  9. Cao F, Chen SS, Yan XF, et al. Evaluation of side effect through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventromedial medulla with dermorphin-saporin. Neurotoxicology. 2009, 30(6): 1096-1106. (Co-first author)

Awards & Honors

  • 1998-1999 Class Two Academic Excellence Scholarship
  • 1998-1999 Excellent Student Leader
  • 1999-2001 “Three Goods” Student Scholarship
  • 2001 First prize in Graduation Examination
  • 2001-2002 University Academic Excellence Scholarship
  • 2001-2002 “Three Goods” graduate student Scholarship
  • 2002-2003 Public/Society Benefit Scholarship
  • 2004 Grade 2004 Excellent Graduate Student Scholarship
  • 2004-2005 Excellent Postgraduate Cadre of HUST
  • 2004-2005 Excellent Postgraduate dissertation of HUST
  • 2006 Excellent Master dissertation of Hubei Province
  • 2007 Grade 2007 Excellent Graduate student Scholarship

Project Interest & Description

I am the lab manager of Yong Xu’s Laboratory. I succor everyone's daily laboratory needs, which include : mouse husbandry, maintain the mouse colony, run all of the genotyping for the mice, preparing buffers and working solutions, scheduling, ordering, and training new post-docs or visiting scholars on surgical procedures.

Fun Fact

I love to be organized and everything being in order. I also enjoy being social and other peoples company.


Jay Morris, Ph.D.Fang Zou, Ph.D.

Education

BS Biochemistry, College of Life Sciences, Sichuan University, Sichuan, China, 2001
Ph.D Microbiology, Advisor: Dr. Jian-Guo Wu, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Hubei, China, 2007

Previous Publications

  1. Zhu L, Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O’Malley BW, Xu Y. Steroid receptor co-activator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 2012 (in press).
  2. Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ. (2011) DIstinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metabolism 14:453-65. Independent citation: 8.
  3. Song D, Zou F, Wu K, Liu Y, Zhu Y, Wu J. (2007) Roles of Wilm’s tumor suppressor (WTI) in the regulation of human inducible Nitric Oxide synthase gene (hiNOS). Chemical Journal of Chinese University. 10:1907-1910.
  4. Zhang Z, Cai YQ, Zou F, Bie B, Pan ZZ. (2011)Epigenetic suppression of GAD65 expression mediates persistent pain. Nature Medicine.17:1448-1455. Independent citation: 5.
  5. Zou F, Liu Y, Liu L, Wu K, Wei W, Zhu Y, Wu J.(2007) Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARα/RXRα heterodimer to a Retinoic Acid Response Element in the Promoter. Biochemical and Biophysical Research Communications. 355:494-500. Independent citation: 10. (Co-first author)

Murli ManoharYongjie Yang, Ph.D.

Education

Ph.D Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences(CAS). Shanghai, China, 2005
BS Department of Bioengineering, Huazhong University of Science and Technology, Wuhan, China, 199

Publications

  1. Zhu L, Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O’Malley BW, Xu Y. Steroid receptor co-activator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 2012 (in press).
  2. Yang Y, Chen K, Tong Q. Murine SIRT3 Protein Isoforms Have Variable Half-lives. Gene. 2011; 488(1-2):46-51.
  3. Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem. 2010;111(4):1051-8.
  4. Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem. 2010; 285(10):7417-29.
  5. Cimen H, Han MJ, Yang Y, Tong Q, Koc H, Koc EC. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry. 2010; 49(2):304-11.

Fun Fact

I enjoy a good laugh!


Hui Mei, Ph.D.Pingwen Xu, M.S., Ph.D

Education

Ph.D. Animal and Poultry Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, 2011
MS Animal Science, South China Agriculture University, Guangzhou, Guangdong, 2007
BS Animal Science, South China Agriculture University, Guangzhou, Guangdong, 2004

Publications

  1. Zhu L, Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O’Malley BW, Xu Y. Steroid receptor co-activator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 2012 (in press).
  2. Xu, P., P. B. Siegel, and D. M. Denbow. 2011. Genetic selection for body weight in chickens has altered responses of the brain’s AMPK system to feed regulation effect of ghrelin, but not obestatin. Behavioural Brain Research. 221(1):216-226.
  3. Xu, P., P. B. Siegel, and D. M. Denbow. 2011. AICAR and Compound C regulates food intake independently of AMP-activated protein kinase in lines of chickens selected for high or low body weight. Comparative Biochemistry and Physiology. Part A. Molecular & Integrative Physiology. 159(4):401-412.
  4. Xu, P., D. M. Denbow, N. Meiri, and C. J. Denbow. 2011. Fasting of 3-day-old chicks leads to changes in histone H3 methylation status. Physiology & Behavior. 105(2):276-282.
  5. Xu, P., X. Fang, G. Shu, X. Zhu, Z. Luo, Q. Jiang, P. Gao, and Y. Zhang. 2010. Prokaryotic expression of Gly-Gln dipeptide and its bioactive analysis: a novel method for short peptide production. Agricultural Sciences in China. 9:101-105.
  6. Zou, S., A. Zhi, X. Zhou, J. Zuo, Y. Zhang, Z. Huang, P. Xu, D. Feng. 2009. Molecular Cloning, Segmental Distribution and Ontogenetic Regulation of Cationic Amino Acid Transporter 2 in Pigs. Asian-Aust. Journal of Animal Science. 22(5):712-717.
  7. Shu, G., P. Gao, X. Zhu, Q. Jiang, P. Xu, G. Zhou, F. Sun, and W. Fu. 2007. Effects of glycyl-glutamine on the growth performance and lipid deposition in Yue-Huang broilers. Journal of Animal and Feed Sciences. 16:232-240.
  8. Zhu, X., Z. Cui, P. Gao, Q. Jiang, G. Shu, P. Xu, and W. Fu. 2005. Effect of glycyl-glutamine on immune functions of Yuehuang chicken. Acta Veterinaria et Zootechnica Sinica. 36:956-959.

Awards & Honors

American Heart Association SouthWest Affiliate Summer 2012 Postdoctoral Fellowship

Project Interest & Description

My research interests lie in understanding the specific estrogen receptor and the action sites that are essential to produce metabolic benefits. I focus on which specific brain regions estrogen acts on to regulate body weight. In particular, I am trying to determine if the amygdala, a brain region traditionally known to regulate emotions and behavior, is critical for estrogen effects on body weight.

Fun Fact

I can bend the top joint of my fingers without bending the lower joint, while most people can't do it!