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CNRC - Mouse Metabolic Research Unit

Houston, Texas

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CNRC - Mouse Metabolic Research Unit
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Quantitative Magnetic Resonance (QMR)

Request use of QMR »

Quantitative Magnetic Resonance

Capabilities

The MMRU is equipped with an EchoMRI-100® QMR instrument that provides precise measurements of total body fat, lean mass, and body fluids in live mice up to 100 g. The measurement can be made in 2 to 4 minutes and does not require that the mouse be anesthetized or sedated.

Body composition measurement method

The instrument determines the extent to which the protons present in lean and fat tissue perturb a magnetic field. This has been calibrated so that the output can be interpreted in terms of fat and lean masses. The technique is noninvasive, nondestructive, does not require that the animal be sedated and causes no pain or stress. To perform these measurements the mouse is placed in a Plexiglas tube (6 cm in diameter and restrained to a length of approximately 5 cm according to the size of the mouse), and is placed in the instrument's magnetic field. Readings are taken over a period of 2 to 4 minutes, after which the mouse is removed and returned to its cage.

Request and use procedure

Note: New users must first go through training on instrument calibration, making measurements, and data access.

  1. Email Dr. Marta Fiorotto stating your approved animal protocol number, charge source, when you wish to use it, for how long, and if you have used the instrument before or need instruction. If you have access to the online QMR calendar, you can request time directly.
  2. You will receive approval by e-mail. The QMR is housed in the MMRU suite of the CNRF.