Baylor College of Medicine
The unprecedented growth of technology during the past decade has created a challenging situation for today's researcher. Powerful computers and related data acquisition equipment allows one to accumulate information much faster than before. Processing this information, however, is not trivial. The Body Composition Laboratory houses a number of sophisticated instruments designed to measure the elemental composition of the human body using nuclear-based techniques. Each of these instruments is in a dynamic state of evolution. In addition to processing thousands of measurements each year, we are constantly working to improve the accuracy and sensitivity of each device. Additionally, the information that does come from these measurements must be efficiently managed and distributed. New measurement systems are being developed as well:
*A multi-parameter whole body counter capable of isolating and measuring a signal coming from a specific site of the body.
*A portable 40K counter for use in a hospital setting.
Coordinating this effort, as well as incorporating new technology, is my main focus.
Abrams SA, Griffin IJ, Hawthorne KM, Chen Z, Gunn SK, Wilde M, Darlington G, Shypailo RJ, Ellis KJ. Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. J Bone Miner Res. 20(6):945-953, 2005.
Shypailo RJ, Ellis KJ. Bone Assessment in Children: Comparison of Fan-Beam DXA Analysis. J Clin Densitom. 8(4):445-453, 2005.
Koo WW, Hammami M, Shypailo RJ, Ellis KJ. Bone and body composition measurements of small subjects: discrepancies from software for fan-beam dual energy X-ray absorptiometry. J Am Coll Nutr. 23(6):647-650, 2004.
Ellis KJ, Shypailo RS, Steinberg FM, Lewis RD, Young RL, Wong WW. Reproducibility of fan-beam DXA measurements in adults and phantoms. J Clin Densitom. 7(4):413-418, 2004.
Ellis KJ, Shypailo RJ, Wong WW, Abrams SA. Bone mineral mass in overweight and obese children: diminished or enhanced? Acta Diabetol. 40(Suppl 1):S274-S277, 2003.
Ellis KJ, Shypailo RJ, Hardin DS, Perez MD, Motil KJ, Wong WW. Z score prediction model for assessment of bone mineral content in pediatric diseases. J Bone Miner Res 2001; 16(9): 1658-1664.
Shypailo RJ, Ellis KJ. Estimation of background interference in prompt-gamma neutron activation using MCNP. J Radioanal Nucl Chem 2001; 249(2): 407-412.
Shypailo RJ, Ellis KJ. Educational web site: Radioisotopic methods of determining body composition. J Radioanal Nucl Chem 2001; 249(2): 403-406.
Shypailo RJ, Ellis KJ. Accuracy of dual-energy x-ray absorptiometry in infant scans: an assessment using anthropomorphic phantoms. Annals NY Acad Sci 2000; 904: 98-100.