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USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine



Kazumi Ishimura-Oka, MD

Assistant Professor
Baylor College of Medicine

Regulation of lipid metabolism

The primary goal of my research is to define the mechanisms by which lipid metabolism is regulated in normal and pathological conditions. We have been studying the physiological roles of enzymes and lipoprotein receptors involved in complex lipoprotein dynamics employing the molecular biology techniques. The protein of our current major interests is lipoprotein lipase (LPL). We have generated adipose tissue-specific-LPL transgenic mice. Using this animal model, we will determine the tissue-specific effects of LPL in lipid metabolism with regards to metabolic disorders such as obesity, atherosclerosis and diabetes. Other protein of interests is very low density lipoprotein receptor (VLDLR). Overexpression of VLDLR has been shown to ameliorate hypercholesterolemia in LDL receptor knockout mice using adenovirus-mediated somatic gene transfer. We plan to study the role of VLDLR in obesity development and lipid nutrient delivery. Our study will help understand the molecular basis for lipid abnormalities and develop gene therapy for genetic disorders.

Representative publications:

Ishimura-Oka K, Faustinella F, Kihara S, Smith LC, Oka K, Chan L. A missense mutation (Trp86 Arg) in exon 3 of the lipoprotein lipase: a cause of familial chylomicronemia. Am J Hum Genet 1992;50:1275-1280.

Kobayashi K, Oka K, Teng BB, Ishimura-Oka k, Forte T, Ishida B, Chan L. Adenovirus-mediated gene transfer of VLDL receptor reversed hypercholesterolemia in mice lacking LDL receptor. J Biol Chem 1996;224:975-982.

Oka K, Ishimura-Oka K, Chu MJ, Chan L. Transcription of the human Hepatic lipase gene is modulated by multiple negative elements in HepG2 cells. Gene 1996;180:69-80.

Oka K, Kobayashi K, Kovar M, Martinez J, Teng BB, Ishimura-Oka K, Chan L. Tissue- specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus mediated transfer of a dominant negative mutant APOBEC-1 lead to increased low density lipoprotein in mice. J Biol Chem 1997;272:1456-1460.

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