Venezia by PVII

Craig L. Jensen, MD

Assistant Professor of Pediatrics
Baylor College of Medicine

Attending Physician
Section of GI and Nutrition
Texas Children's Hospital

Lipid and Carbohydrate Metabolism in Preterm Infant

The primary objective of my research is to increase understanding of the impact of the composition of dietary non-protein carbon sources on growth and development of term and preterm infants. Important issues to be resolved include the need for specific fatty acids in the diet during early life, the metabolic effects of medium-chain triglycerides and the effects of the distribution of non-protein energy intake between lipid and carbohydrate on growth, nitrogen retention, substrate utilization, energy expenditure and endocrine response.

Currently, we are determining the ability of infants to convert the parent fatty acids of the _6 and _3 fatty acid families to longer-chain, more unsaturated derivatives of each family and the effect of the dietary _6/_3 fatty acid ratio on this ability. We are addressing these questions by administering U-13C-labeled 18:2_6 and 18:3_3 and determining the incor-poration of label into 20:4_6 and 22:6_3. These data will be used to select 20:4_6 and 22:6_6 supplements for infant formulas, and the effects of these supplements on visual acuity and neurodevelopmental outcome will be determined.

Studies of the effects of different energy sources (e.g., fat vs. carbohydrate; medium-chain vs. long-chain triglycerides) on growth, protein utilization, energy expenditure and body composition of preterm infants are expected to begin soon. These will include careful deter- minations of lipid and carbohydrate metabolism using 13C-labeled substrates.

Representative publications:

Jensen CL, Voigt RG, Prager TC, Zou YL, Fraley JK, Rozelle JC, Turcich MR, Llorente AM, Anderson RE, Heird WC. Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. Am J Clin Nutr. 82(1):125-132, 2005.

Voigt RG, Brown FR 3rd, Fraley JK, Llorente AM, Rozelle J, Turcich M, Jensen CL, Heird WC. Concurrent and predictive validity of the cognitive adaptive test/clinical linguistic and auditory milestone scale (CAT/CLAMS) and the Mental Developmental Index of the Bayley Scales of Infant Development. Clin Pediatr (Phila). 42(5):427-432, 2003.

Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WC. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. Am J Obstet Gynecol. 188(5):1348-1353, 2003.

Jensen C.L., Butte N.F., Wong W.W., Moon J.K. "Determining energy expenditure in preterm infants: comparison of 2H218O method and indirect calorimetry." Am J Physiol, 1992; 263:R685- 92.

Moon J.K., Jensen C.L., Butte N.F. "Fast response whole body indirect calorimeters for infants." J Appl Physiol, 1993; 476-84.

Jensen, C.L., Chen, H., Fraley, J.K., Anderson, R.E., Heird, W.C. "Biochemical effects of dietary linoleic/2-linolenic acid ratio in term infants." Lipids, 1996; 31: 107-113.

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