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Children's Nutrition Research Center - Faculty

Houston, Texas

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Children's Nutrition Research Center - Faculty
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Agus Suryawan, Ph.D.

Instructor of Pediatrics, Baylor College of Medicine

E-mail: suryawan@bcm.edu

Research Interests

The Role of Growth Factors on the Regulation of Protein Synthesis in Skeletal Muscle of Neonates

Early postnatal period is characterized by rapid growth, particularly in skeletal muscle. Our previous observations indicate that higher rate of skeletal muscle protein synthesis in neonates is partly due to increased activation of insulin signaling components leading to translation initiation. Despite tremendous efforts, the factors that regulate high rate of skeletal muscle protein synthesis are not completely understood.

The growth of skeletal muscle during the prenatal and early postnatal period is in part governed by growth factors that act as positive and negative regulators. Studies indicate that the transforming growth factor-beta (TGF- b ) superfamily encompasses a large group of growth and differentiation factors that play important roles in the positive and negative regulation of embryonic and postnatal skeletal muscle development. One particularly interesting growth factor is follistatin. This high-affinity, secreted binding protein was originally considered to be an activin bioneutralizer involved in reproduction. However, recent biochemical and genetic studies have shown that follistatin positively regulates skeletal muscle growth. The potential role of follistatin and other growth factors on skeletal muscle growth in neonates warrants investigation.

My current interests focus on understanding the role of follistatin and its binding partners in regulating skeletal muscle growth in neonate. To achieve these goals, our group is studying the effect of follistatin on the regulation of skeletal muscle growth by determining its effects on protein synthesis and the activation of insulin signaling proteins and translation initiation factors.

Representative Publications

Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Regulation of Cardiac and Skeletal Muscle Protein Synthesis by Individual Branched-Chain Amino Acids in Neonatal Pigs. Am J Physiol Endocrinol Metab. 290(4):E612-E621, 2005.

Suryawan A, Davis TA. Developmental regulation of protein kinase B activation is isoform specific in skeletal muscle of neonatal pigs. Pediatr Res. 58(4):719-724, 2005.

Frank JW, Escobar J, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Dietary Protein and Lactose Increase Translation Initiation Factor Activation and Tissue Protein Synthesis in Neonatal Pigs. Am J Physiol Endocrinol Metab. 290(2):E225-E233, 2005.

Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Whole-body and hindlimb protein breakdown are differentially altered by feeding in neonatal piglets. J Nutr. 135(6):1430-1437, 2005.

Frank JW, Escobar J, Suryawan A, Kimball SR, Nguyen HV, Jefferson LS, Davis TA. Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein. J Nutr. 135(6):1374-1381, 2005.

Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am J Physiol Endocrinol Metab. 288(5):E914-E921, 2005.

O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs. Am J Physiol Endocrinol Metab. 286(6):E994-E1003, 2004.

Orellana RA, Kimball SR, Nguyen HV, Bush JA, Suryawan A, Thivierge MC, Jefferson LS, Davis TA. Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia. Pediatr Res. 55(3):442-449, 2004.

Sweatt AJ, Wood M, Suryawan A, Wallin R, Willingham MC, Hutson SM. Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves. Am J Physiol Endocrinol Metab. 286(1):E64-E76, 2004.

Davis TA, Bush JA, Vann RC, Suryawan A, Kimball SR, Burrin DG. Somatotropin regulation of protein metabolism in pigs. J Anim Sci. 82(E-Suppl):E207-E213, 2004.

Suryawan A, O'Connor PM, Kimball SR, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs. J Nutr. 134(1):24-30, 2004.

Kimball SR, Orellana RA, O'Connor PM, Suryawan A, Bush JA, Nguyen HV, Thivierge MC, Jefferson LS, Davis TA. Endotoxin induces differential regulation of mTOR dependent signaling in skeletal muscle and liver of neonatal pigs. Am J Physiol Endocrinol Metab. 285(3):E637-E644, 2003.

Suryawan A, Nguyen HV, Orellana RA, Bush JA, Davis TA. Insulin/insulin-like growth factor-I hybrid receptor abundance decreases with development in suckling pigs. J Nutr. 133(9):2783-2787, 2003.

O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab. 285(1):E40-E53, 2003.

Bush JA, Kimball SR, O'Connor PM, Suryawan A, Orellana RA, Nguyen HV, Jefferson LS, Davis TA. Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs. Endocrinology. 144(4):1273-1283, 2003.

Bush JA, Burrin DG, Suryawan A, O'Connor PM, Nguyen HV, Reeds PJ, Steele NC, Van Goudoever JB, Davis TA. Somatotropin-induced protein anabolism in hindquarters and portal-drained viscera of growing pigs. Am J Physiol Endocrinol Metab. 284(2):E302-E312, 2003.

Suryawan A, Davis TA. Protein-tyrosine-phosphatase 1B activation is regulated developmentally in muscle of neonatal pigs. Am J Physiol Endocrinol Metab. 284(1):E47-E54, 2003.

O'Connor PM, Bush JA, Suryawan A, Nguyen HV, Davis TA. Insulin and amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs. Am J Physiol Endocrinol Metab. 284(1):E110-E119, 2003.

Suryawan A , Nguyen HV, Bush JA, Davis TA. Developmental changes in the feeding-induced activation of the insulin-signaling pathway in neonatal pigs. Am J Physiol Endocrinol Metab 2001; 281:E908-15.

Davis TA, Nguyen HV, Suryawan A , Bush JA, Jefferson LS, Kimball SR . Developmental changes in the feeding-induced stimulation of translation initiation in skeletal muscle and liver of neonatal pigs. Am J Physiol Endocrinol Metab. 2000; 279: E1226-34.

Suryawan A, Hawes J, Shimomura J, Harris R, Jenkins A, Hutson S. A molecular model of branched chain amino acid metabolism in human. Am J Clin Nutr 1998; 68: 72-81.

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