Robert J. Shulman, M.D.
Professor of Pediatrics, Baylor College of Medicine, Children’s Nutrition Research Center,
Director, Center for Pediatric Abdominal Pain Research, Texas Children's Hospital
Around the world, between 10-17% of school age children have abdominal pain disorders such as functional abdominal pain, irritable bowel syndrome, and dyspepsia. Our goals are to understand the factors contributing to the development of these conditions and to develop effective treatments and management strategies. We are addressing these disorders using a multidisciplinary approach involving collaboration between basic scientists, clinical research scientists, practicing physicians, psychologists, and nurses.
Areas of research we are investigating include the roles of:
c) An altered composition of bacteria in the gut
d) Gut barrier dysfunction
e) Psychosocial distress
f) Alterations in central and peripheral nervous system processing
g) Probiotics, fiber, and other modalities for treatment
Chumpitazi BP, Hollister EB, Oezguen N, Tsai CM, McMeans, Luna RA, Savidge TC, Versalovic J, Shulman RJ. Gut Microbiota Influences Low Fermentable Substrate Diet Efficacy in Children with Irritable Bowel Syndrome. Gut Microbes [in press].
Mayer EA, Savidge T, Shulman RJ. Brain Gut Microbiome Interactions and Functional Bowel Disorders. Gastroenterology [in press]
Shulman RJ, Jarrett ME, Cain KC, Broussard E, Heitkemper MM. Associations among Gut Permeability, Inflammatory Markers and Symptoms in Patients with Irritable Bowel Syndrome. J Gastroenterol [in press].
Williams AE, Self MM, Czyzewski DI, Shulman RJ. Are child anxiety and somatization associated with pain in pain-related functional gastrointestinal disorders? J Health Psychol 2013 [Epub ahead of print]
Di Nardo G, Barbara G, Cucchiara S, Cremon C, Shulman RJ, Isoldi S, Zecchi L, Drago L, Oliva S, Sauller R, Barbaro R, Stronati L. Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS. Neurogastroenterol Mot 2013 [Epub ahead of print]
Self MM, Czyzewski DI, Chumpitazi BP, Weidler EM, Shulman RJ. IBS Subtypes in Children and Adolescents with Irritable Bowel Syndrome. Clin Gastroenterol Hepatol [in press].
Carlson M, Moore C, Tsai CM, Shulman RJ, Chumpitazi BP. Child and Parent Perceived Food-Induced Gastrointestinal Symptoms and Quality of Life in Children with Functional Gastrointestinal Disorders. J Acad Nutr Diet 2013 [Epub ahead of print]
Rafati DS, Shulman RJ. Mucosal permeability testing: Should interpretation change or stay the same? Neurogastroenterol Motil 2013t;25:854.
Williams AE, Heitkemper M, Self MM, Czyzewski DI, Shulman RJ. Endogenous Inhibition of Somatic Pain is Impaired in Girls with Irritable Bowel Syndrome Compared with Healthy Girls. J Pain 2013;14:921-30. PMCID:PMC3759538
Saulnier DM, Ringel Y, Heyman MB, Foster JA, Bercik P, Shulman RJ, Versalovic J, Verdu E, Dinan TG, Hecht GA, Guarner F. The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes 2012; 4:17-27. PMCID:PMC3555881
Goo YA, Cain K, Jarrett M, Smith L, Voss J, Tolentino E, Tsuji J, Tsai Y, Panchaud A, Goodlett D, Shulman RJ, Heitkemper M. Urinary proteome analysis of irritable bowel syndrome symptom subgroups. J Proteom Res 2012; 11:5650-5662. PMCID: PMC3631108
Shulman RJ. Dietary issues in recurrent abdominal pain. J Pediatr Gastroenterol Nutr 2012;55 Suppl 2:S40-42. PMC Journal - In Process
Jarrett M, Heitkemper M, Czyzewski DI, Zeltzer L, Shulman RJ. Autonomic Nervous System Function in Young Children with Functional Abdominal Pain or Irritable Bowel Syndrome. J Pain 2012;13:477-484. PMCID:PMC3566525
Shulman RJ, Smith EO. Does VSL#3 really improve symptoms in children with irritable bowel syndrome? J Pediatr Gastroenterol Nutr 2012;54:109.
Saulnier DM, Riehle K, Mistretta T-A, Diaz M-A, Mandal D, Raza S, Weidler EM, Qin X, Coarfa C, Milosavljevic A, Petrosino JF, Highlander S, Gibbs R, Lynch SV, Shulman RJ, Versalovic J. Microbial signatures present in gut microbiomes of pediatric irritable bowel syndrome. Gastroenterology 2011;141:1782-1791. PMCID: PMC3417828
Lane MM, Czyzewski DI, Chumpitazi BP, Shulman RJ. Reliability and Validity of a Modified Bristol Stool Form Scale for Children. J Pediatr 2011;159:437-441. PMCID:PMC3741451
Czyzewski DI, Lane MM, Weidler EM, Williams AE, Swank PR, Shulman RJ. Interpretation of Rome III Criteria and Method of Assessment Affect IBS Classification of Children. Aliment Pharmacol Ther 2011;33:403-411. PMC Journal - In Process
Chumpitazi BP, Lane MM, Czyzewski DI, Weidler EM, Swank PR, Shulman RJ. Creation and initial evaluation of a stool form scale for children. J Pediatr 2010;157:594-597. PMCID: PMC2937014
McOmber ME. Ou C-N, Shulman RJ. Effects of timing, sex, and age on site-specific gastrointestinal permeability testing in children and adults. J Pediatr Gastroenterol Nutr 2010;50:269-275. PMCID: PMC2830368
Thakkar K, Chen L, Tatevian N, Shulman RJ, McDuffie A, Tsou M, Gilger MA, El-Serag HB. Diagnostic yield of EGD in children with abdominal pain. Aliment Pharmacol Therap 2009; 30:662-669. PMCID: PMC3018747
Lane MM, Weidler EM, Czyzewski DI, Shulman RJ. Pain Symptoms and Stooling Patterns Do Not Drive Diagnostic Costs for Children with Functional Abdominal Pain and Irritable Bowel Syndrome in Primary or Tertiary Care. Pediatrics 2009;123:758-764. PMCID:PMC2821591
Shulman RJ, Eakin MN, Czyzewski DI, Jarrett M, Ou C-N. Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome. J Pediatr 2008;153:646-650. PMCID: PMC2614282
Czyzewski DI, Eakin MN, Lane MM, Jarrett M, Shulman RJ. Recurrent Abdominal Pain in Primary and Tertiary Care: Differences and Similarities. Child Health Care 2007;36:137-153. PMCID: PMC2847419
Shulman RJ, Eakin MN, Jarrett M, Czyzewski DI, Zeltzer LK. Characteristics of Pain and Stooling in Children with Recurrent Abdominal Pain. J Pediatr Gastroenterol Nutr 2007;44:203-208. PMCID: PMC2826272