Venezia by PVII

Dr. HaymondMorey W. Haymond, M.D.

Professor of Pediatrics
Baylor College of Medicine
mhaymond@bcm.tmc.edu

Director, Diabetes Care Center
Section of Endocrinology
Texas Children's Hospital

Hormonal Regulation of Nutrient Oxidation

The focus of my research program is to delineate and ultimately manipulate the hormone and substrate factors that regulate the absorption, assimilation, mobilization and disposal of carbohydrates in infants and children.  The delicate balance of nutrient availability to meet the energy and growth needs of children are frequently disturbed as a result of chronic disease, infection, trauma and/or organ failure.  In addition, the increasing incidence of both type I and type II diabetes provides unique opportunities to study the effects of insulin, insulin resistance and obesity on macronutrient assimilation in children.

These issues are being addressed in infants, children, and adults and, when necessary, in animals.  Specific studies utilize a variety of stable isotopic tracer techniques to estimate insulin sensitivity, absorption of carbohydrates, proteolysis, protein synthesis, gluconeogenesis, carbohydrate disposal, and substrate oxidation. 

Studies currently underway explore the impact of diet composition (fat and carbohydrate) on glucose homeostatis and macronutrient accretion, the impact of lactation on glucose homeostasis, the precursors for lactose production by the mammary gland as well as the factor(s) which regulate it, and the regulation of galactose and fructose metabolism by the liver.

The primary research tools employed are GC/MS, GC/combustion/IR/MS, IR/MS, indirect calorimetry and standard hormone and substrate analyses.  These sophisticated analytical techniques, together with well-controlled study designs, permits us to address a number of fundamental questions in the assimilation and disposal of macronutrients in children.

Representative publications:

Sunehag AL, Toffolo G, Campioni M, Bier DM, Haymond MW. Effects of dietary macronutrient intake on insulin sensitivity and secretion and glucose and lipid metabolism in healthy, obese adolescents. J Clin Endocrinol Metab. 90(8):4496-502, 2005.

Heptulla RA, Rodriguez LM, Bomgaars L, Haymond MW. The role of amylin and glucagon in the dampening of glycemic excursions in children with type 1 diabetes. Diabetes. 54(4):1100-1107, 2005.

Mauras N, Haymond MW. Are the metabolic effects of GH and IGF-I separable? Growth Horm IGF Res. 15(1):19-27, 2005.

Jeha GS, Karaviti LP, Anderson B, Smith EO, Donaldson S, McGirk TS, Haymond MW. Continuous glucose monitoring and the reality of metabolic control in preschool children with type 1 diabetes. Diabetes Care. 27(12):2881-2886, 2004.

Kaplan W, Rodriguez LM, Smith OE, Haymond MW, Heptulla RA. Effects of mixing glargine and short-acting insulin analogs on glucose control. Diabetes Care. 27(11):2739-2740, 2004.

Meyer C, Stumvoll M, Welle S, Woerle HJ, Haymond M, Gerich J. Relative importance of liver, kidney, and substrates in epinephrine-induced increased gluconeogenesis in humans. Am J Physiol Endocrinol Metab. 285(4):E819-E826, 2003.

Haymond MW. Measuring insulin resistance: a task worth doing. But how? Pediatr Diabetes. 4(3):115-118, 2003.

Sunehag AL, Haymond MW. Maternal protein homeostasis and milk protein synthesis during feeding and fasting in humans. Am J Physiol Endocrinol Metab. 285(2):E420-E426, 2003.

Treuth MS, Sunehag AL, Trautwein LM, Bier DM, Haymond MW, Butte NF. Metabolic adaptation to high-fat and high-carbohydrate diets in children and adolescents. Am J Clin Nutr. 77(2):479-489, 2003.

Sunehag A, Tigas S, Haymond MW. Contribution of plasma galactose and glucose to milk lactose synthesis during galactose ingestion. J Clin Endocrinol Metab. 88(1):225-229, 2003.

Tigas S, Sunehag AL, Haymond MW. Impact of duration of infusion and choice of isotope label on isotope .recycling in glucose homeostasis. Diabetes. 2002 Nov;51(11):3170-5.

Sunehag AL, Toffolo G, Treuth MS, Butte NF , Cobelli C, Bier DM, Haymond MW. Effects of dietary macronutrient content on glucose metabolism in children. J Clin Endocrinol Metab 87:5168-5178, 2002

Mauras N, George D, Evans J, Milov D, Abrams, S, Rini A, Welch S, Sunehag A , Louie K, Bier JL, Tigas A, Haymond MW : Hexoneogenesis in the Human Breast during Lactation J. Clin. Endocrinol. Metab. 87: 297-301, 2002.

Sunehag AL, Haymond MW. Splanchnic Galactose Extraction is Regulated by Co-ingestion of Glucose in Humans. Metabolism 5: 827-832, 2002..

Haymond, MW: Growth Hormone has anabolic effects in glucocorticosteroid-dependent children with Inflammatory Bowel Disease: a pilot study. Metabolism. 51:127-35. 2002 .

Tigas S, Sunehag A , Haymond MW: Metabolic Adaptation to Feeding and Fasting during Lactation in Humans J. Clin. Endocrinol. Metab. 87: 302-307, 2002.

Meyer Ch, Stumvoll M, Dostou J, Welle S, Haymond M, Gerich J: Renal substrate exchange and gluconeogenesis in normal postabsorptive humans Am J Physiol Endocrinol Metab 282: E428-E434, 2002.

 

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