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USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine

 
   

   

Peter M. Haney, MD, PhD

Assistant Professor of Pediatrics/Section of Neonatology
Baylor College of Medicine
phaney@bcm.tmc.edu

Attending Physician
Section of Neonatology
Texas Children's Hospital

B.S. University of Scranton, Scranton, Pennsylvania
Ph.D., Biochemistry, Case Western Reserve University, Cleveland, Ohio
M.D. Case Western Reserve University School of Medicine, Cleveland, Ohio



Regulation of Glucose Transport in Lactating Mammary Gland

The long-term goal of my research is to understand the molecular cell biology of lactation.

Current work is focused on glucose transport in lactating mammary gland.  Since glucose is the key substrate for the synthesis of lactose, the major osmotic constituent of human milk, it is the major determinant of the volume of milk produced.  Glucose also is a key substrate for the synthesis of lipid, the major determinant of the caloric concentration of human milk.  I am studying the regulation of the amount, activity, and subcellular targeting of GLUT1, the only glucose transporter isoform identified in mammary gland, in established and primary mammary epithelial cell lines as well as in humans and rodents.  Efforts are underway to elucidate the mechanisms of altered glucose transporter targeting, including Golgi sequestration and polarization of plasma membrane distribution, that we have observed during lactation and to understand the impact of GLUT1 retargeting and of altered GLUT1 gene expression on lactose synthesis and milk production.  An artificial rearing system to study nutrient-gene interactions and possible programming effects in the regulation of glucose transport during rodent development .


Representative Publications:

Haney PM, Levy MA, Strube MS, Mueckler M. Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail. J Cell Biol 1995; 129:641-658.

Nemeth BA, Tsang SWY, Geske, RS, Haney PM. Golgi targeting of the GLUT1 glucose transporter in lactating mouse mammary gland. Pediatr Res 2000; 47:444-450.

Haney, P.M. Targeting of the GLUT1 glucose transporter to Brefeldin A-sensitive vesicles of CIT3 mouse mammary epithelial cells. Cell Biology Internat. 2001; 25:277-288.

Abstracts

Riskin, A, Nannegari, VH, Haney, PM. GLUT1 colocalizes with the proteins of lactose synthetase and with endosomes in human mammary epithelial cells. Ped Res 2000; 47:296A (SPR poster presentation).

Riskin, A, Nannegari, VH, Haney, PM. An intact endosomal pathway is required for normal targeting of GFP-GLUT1 glucose transporter fusion proteins in living mouse mammary epithelial cells. Ped Res 2000; 47:296A (SPR poster symposium presentation).

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