Venezia by PVII

Alexandre LapillonneAlexandre Lapillonne, M.D., Ph.D.

Assistant Professor of Pediatrics
Baylor College of Medicine
Phone: (713) 798-7198
Fax: (713) 798-7187

Early Nutrition and Quality of Growth

My primary research interest is to determine if, and how, an early nutritional event may have long-term effects on quality of growth, metabolic functions and development. My work has focused on the most common nutritional problems during early life: the effect of intrauterine growth on body composition and postnatal growth; the effects of specific nutrients on gene transcription; how alterations in gene transcription affect growth and body composition.

My current research focuses specifically on the effect of n-3 polyunsaturated fatty acids on weight gain, body composition, fat oxidation, energy expenditure and transcription of genes controlling lipid oxidation and thermogenesis. This area of research is being pursued collaboratively with Dr William C. Heird at the CNRC and Dr. Steven D. Clarke, University of Texas, Austin. A planned project will assess how and when in early life, optimization of protein intake will maximize catch-up growth and neurological development of very low birth weight infants. The overall goal of my research is to optimize the nutritional management of extremely low-birth weight infants in order to overcome long lasting effects on growth and development.

Each project employs a wide variety of tools of in vivo investigation (e.g., standard anthropometry, indirect calorimetry, body composition assessment, stable isotope methodologies) as well as molecular biology techniques (e.g., Northern Blot, DNA microarray analysis).

Representative Publications:

Heird WC, Lapillonne A. The role of essential fatty acids in development. Annu Rev Nutr. 25:549-571, 2005.

Lapillonne A, Clarke SD, Heird WC. Polyunsaturated fatty acids and gene expression. Curr Opin Clin Nutr Metab Care. 7(2):151-156, 2004.

Lapillonne A, Clarke SD, Heird WC. Plausible mechanisms for effects of long-chain polyunsaturated fatty acids on growth. J Pediatr. 143(4 Suppl):S9-S16, 2003.

Ding ST, Lapillonne A, Heird WC, Mersmann HJ. Dietary fat has minimal effects on fatty acid metabolism transcript concentrations in pigs. J Anim Sci. 81(2):423-431, 2003.

Lapillonne A, Carlson SE. Polyunsaturated fatty acids and infant growth. Lipids 2001, in press.

Lapillonne A, Picaud JC, Chirouze V et al. The use of low-EPA fish oil for long-chain polyunsaturated fatty acid supplementation of preterm infants. Pediatr.Res. 2000;48:835-41.

Martinez-Botas J, Anderson JB, Tessier D, Lapillonne A et al. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat.Genet. 2000;26:474-9.

Lapillonne A, Hakme C, Mamoux V, Chambon M et al. Effects of liver transplantation on long-chain polyunsaturated fatty acid status in infants with biliary atresia. J.Pediatr.Gastroenterol.Nutr. 2000;30:528-32.

Lapillonne A, Brossard N, Claris O, Reygrobellet B, Salle BL. Erythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months. Eur.J.Pediatr. 2000;159:49-53.

Lapillonne A, Salle BL. Methods for measuring body composition in newborns-a comparative analysis. J.Pediatr.Endocrinol.Metab. 1999;12:125-37.

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