Farook Jahoor, Ph.D.
Professor of Pediatrics, Baylor College of Medicine
Intermediary metabolism in different pathological states
My research focuses on the intermediary metabolism of macronutrient fuels. An area of primary interest currently is the altered metabolic response to the stress of infection and its impact on nutritional requirements during early growth and development. Studies are being performed in both animals and humans to determine how stress alters protein, carbohydrate and lipid metabolism. Another area of research concerns the production of antioxidants and proteins involved in the immune response. I am particularly interested in how production of these important factors are affected by conditions such as protein-energy malnutrition, HIV infection, sepsis, aging and diabetes mellitus. Specific studies focus on the metabolism of glutathione, cysteine, acute phase proteins and nitric oxide. A final area of interest looks at the impact of obesity and undernutrition on certain aspects of the metabolic and physiologic adaptations necessary for a successful pregnancy.
These studies utilize a variety of stable isotopic tracer techniques, some of which have been developed specifically for these studies.
Jahoor F, Badaloo A, Reid M, Forrester T. Protein kinetic differences between children with edematous and nonedematous severe childhood undernutrition in the fed and postabsorptive states. Am J Clin Nutr. 82(4):792-800, 2005.
Sekhar RV, Jahoor F, Pownall HJ, Rehman K, Gaubatz J, Iyer D, Balasubramanyam A. Severely dysregulated disposal of postprandial triacylglycerols exacerbates hypertriacylglycerolemia in HIV lipodystrophy syndrome. Am J Clin Nutr. 81(6):1405-1410, 2005.
Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Whole-body and hindlimb protein breakdown are differentially altered by feeding in neonatal piglets. J Nutr. 135(6):1430-1437, 2005.
Badaloo A, Reid M, Soares D, Forrester T, Jahoor F. Relation between liver fat content and the rate of VLDL apolipoprotein B-100 synthesis in children with protein-energy malnutrition. Am J Clin Nutr. 81(5):1126-1132, 2005.
Shew SB, Keshen TH, Jahoor F, Jaksic T. Assessment of cysteine synthesis in very low birth weight neonates using a [13C6]glucose tracer. J Pediatr Surg. 40(1):52-56, 2005.
Reid M, Forrester T, Badaloo A, Heird WC, Jahoor F. Supplementation with aromatic amino acids improves leucine kinetics but not aromatic amino acid kinetics in infants with infection, severe malnutrition, and edema. J Nutr. 134(11):3004-3010, 2004.
Scaglia F, Brunetti-Pierri N, Kleppe S, Marini J, Carter S, Garlick P, Jahoor F, O'Brien W, Lee B. Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. J Nutr. 134(10 Suppl):2775S-2782S; discussion 2796S-2797S, 2004.
Afolabi, P.R., F. Jahoor, N.R. Gibson and A. A. Jackson. Response of acute phase proteins to the lowering of habitual dietary protein to the recommended safe level of intake. Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E327-30.
Shangraw, R., F. Jahoor. Mechanism of dichloroacetate induced hypolactatemia in humans with cirrhosis. Metabolism. 53, 8, 2004, Pages 1087-1094
Jackson AA, Gibson NR, Lu Y, Jahoor F. Synthesis of erythrocyte glutathione in healthy adults consuming the safe amount of dietary protein. Am J Clin Nutr. 80(1):101-107, 2004.
Sekhar RV, Jahoor F, Pownall HJ, Ballantyne CM, Balasubramanyam A. Cardiovascular implications of HIV-associated dyslipidemic lipodystrophy. Curr Atheroscler Rep. 6(3):173-179, 2004.
Balasubramanyam, A, R. V. Sekhar, F. Jahoor, P.H. Jones, HJ Pownall. Pathophysiology and increased cardiovascular risk in HIV lipodystrophy: a model of systemic steatosis. Curr Opin Lipid. 15: 59-67, 2004.
Jianjian Shi, R. V. Sekhar, A. Balasubramanyam, K. Ellis, P. J. Reeds, F Jahoor, and M. D. Sharma. Short- and long-term effects of growth hormone replacement on protein metabolism in growth hormone deficient adults J Clin Endocrinol Metab. 2003 Dec;88(12):5827-33.
Goodrum, L., G.R. Saade, M A. Belfort, K.J.Moise,Jr., F. Jahoor. Arginine flux and Nitric Oxide Production during human pregnancy and Postpartum . J. Soc Gynecol Investig 10: 400-5, 2003
Jahoor F, Abramson S, Heird WC. The protein metabolic response to HIV infection in young children. Am J Clin Nutr. 2003 Jul;78(1):182-9.
M. Reid, A. Badaloo, T. Forrester, Morlese, J.F, W. Heird, and F. Jahoor. The acute-phase protein response to infection in edematous and nonedematous protein-energy malnutrition. Am J Clin Nutr. 2002 Dec;76(6):1409-1415.
Badaloo, A, Reid, M, T. Forrester, W. C Heird, and F. Jahoor. Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition. Am J Clin Nutr 2002 76: 646-652.