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Children's Nutrition Research Center - Faculty

Houston, Texas

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Children's Nutrition Research Center - Faculty
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Barbara Stoll, Ph.D.

Barbara Stoll, Ph.D.Instructor, Pediatrics, Baylor College of Medicine

E-mail: bstoll@bcm.edu

Education

M.S. Chemistry, Albert-Ludwigs-Universitaet, Freiburg, Germany
Ph.D. Biochemistry, Albert-Ludwigs-Universitaet, Freiburg, Germany
Postdoctoral Fellowship, Pediatric Nutrition, USDA-ARS Children’s Nutrition Research Center, Department of Pediatrics
Research Associate, USDA-ARS Children’s Nutrition Research Center

Research Interests

I am interested in the gut, in particular the small intestine of infant pigs that provides an excellent model for the human infant. I am investigating how luminal nutrients mediate the effects that lead to normal growth and function of the small intestine. Current studies are aimed at investigating the small intestinal metabolic fate of amino acids and glucose in piglets maintained by total parenteral nutrition (TPN), which is a condition where gut growth is greatly compromised.

Grants

2007: Maurice Shils Grant, A.S.P.E.N. Rhoads Research Foundation, American Society for Parenteral and Enteral Nutrition, Insulin Resistance and Gluconeogenesis in TPN-Fed Piglets. Parenteral Nutrition and Hepatic Insulin Resistance in Neonatal Pigs.

2006: CNRC Bristol-Myers Squib: Impact of intestinal microflora and probiotics on host amino acid availability.

Representative Publications

Riedijk MA, Stoll B, Chacko S, Schierbeek H, Sunehag AL, van Goudoever JB, Burrin DG. Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract. Proc Natl Acad Sci U S A (2007) 104:3408-3413.

Lambert BD, Filip R, Stoll B, Junghans P, Derno M, Hennig U, Souffrant WB, Pierzynowski S, Burrin DG. First-pass metabolism limits the intestinal absorption of enteral alpha-ketoglutarate in young pigs. J Nutr (2006) 136:2779-2784.

Wang H, Khaoustov VI, Krishnan B, Stoll B, Burrin DG, Yoffe B. Total parenteral nutrition induces liver steatosis and apoptosis in newborn piglets. J Nutr (2006) 136:2547-2552.

Stoll B, Burrin DG. Measuring splanchnic amino acid metabolism in vivo using stable isotope tracers. J Anim Sci (2006) 84(E. Suppl.):E60-E72.

Stoll B, Price PT, Reeds PJ, Chang X, Henry JF, van Goudoever JB, Holst JJ, Burrin DG. Feeding an elemental versus a milk-based formula does not decrease intestinal mucosal growth in infant pigs. JPEN J Parenter Enteral Nutr (2006) 30:32-29.

Stephens J, Stoll B, Cottrell J, Chang X, Helmrath M, Burrin DG. Glucagon-like peptide-2 acutely increases proximal small intestinal blood flow in TPN-fed neonatal piglets. Physiol Regul Integr Comp Physiol (2006) 59:R283-R289.

Shoveller AK, Stoll B, Ball RO, Burrin DG. Nutritional and functional importance of intestinal sulfur amino acid metabolism. J Nutr (2005) 135:1609-1612.

Schaart MW, Schierbeek H, van der Schoor SR, Stoll B, Burrin DG, Reeds PJ, van Goudoever JB. Threonine utilization is high in the intestine of piglets. J Nutr (2005) 135:765-770.

Niinikoski H, Stoll B, Guan X, Kansagra K, Lambert B, Stephens J, Hartmann B, Holst JJ, Burrin DG. Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets. J Nutr (2004) 134:1467-1474.

Burrin DG, Stoll B, Guan X, Sangild PT, and Petersen YM. GLP-2: a key link between nutrition and intestinal adaptation. J Nutr (2003) 133:3712-3716.

Bos C, Stoll B, Fouillet H, Gaudichon C, Guan X, Grusak MA, Reeds PJ, Tomé D, Burrin DG. Intestinal lysine metabolism is driven by the enteral availability of dietary lysine in piglets fed a bolus meal. Am J Physiol (2003) 285:E1246-E1257.

Burrin DG, Stoll B, Guan X. Glucagon-like peptide 2 function in domestic animals. Domest Anim Endocrinol (2003) 23:103-122.

Van der Schoor SRD, Reeds PJ, Stoll B, Henry JF, Rosenberger JR, Burrin DG, van Goudoever JB. The high metabolic costs of a functional gut. Gastroenterology (2002) 123:1931-1940.

Burrin DG and Stoll B. Key nutrients and growth factors for the neonatal gastrointestinal tract. Clin Perinatol. (2002) 29:65-96.

Reeds PJ, Burrin DG, Davis TA, Fiorotto ML, Stoll B, Van Goudoever JB. Protein Nutrition of the Neonate. Proc Nutr Soc (2000) 59: 87-97.

Stoll B, Chang X, Fan MZ, Reeds PJ, Burrin DG. Enteral nutrient intake determines the rate of intestinal protein synthesis and accretion in neonatal pigs. Am J Physiol (2000) 279:G288-G294.

Burrin DG, Stoll B, Jiang R, Chang X, Hartmann B, Holst JJ, Greeley GH Jr, Reeds PJ. Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: How much is enough? Am J Clin Nutr (2000) 71: 1603-1610.

Stoll B, Burrin DG, Henry J, Yu H, Jahoor F, Reeds PJ. Substrate oxidation by the portal drained viscera of fed piglets. Am J Physiol (1999) 277: E168-E175.

Stoll B, Burrin DG, Henry JF, Jahoor F, Reeds PJ. Dietary and systemic phenylalanine utilization for mucosal and hepatic constitutive protein synthesis in pigs. Am J Physiol (1999) 276: G49-G57.

Stoll B, Henry J, Reeds PJ, Yu H, Jahoor F, Burrin DG. Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J Nutr (1998) 128: 606-614.

Stoll B, Burrin DG, Henry J, Jahoor F, Reeds PJ. Phenylalanine utilization by the gut and liver measured with intravenous and intragastric tracers in pigs. Am J Physiol (1997) 273: G1208-G1217.

vom Dahl S, Stoll B, Gerok W, Häussinger D. Inhibition of proteolysis by cell swelling in the liver requires intact microtubular structures. Biochem J (1995) 308: 529-536.

Stoll B, Gerok W, Lang F, Häussinger D. Liver cell volume and protein synthesis. Biochem J (1992) 287: 217-222.

Stoll B, McNelly S, Buscher HP, Häussinger D. Functional hepatocyte heterogeneity in glutamate, aspartate and alpha-ketoglutarate uptake: a histoautoradiographical study. Hepatology (1991) 13: 247-253.

Häussinger D, Stoll B, Stehle T, Gerok W. Hepatocyte heterogeneity in glutamate metabolism and bidirectional transport in perfused rat liver. Eu J Biochem (1989) 185: 189-195.

Stoll B, Häussinger D. Functional hepatocyte heterogeneity. Vascular 2-oxoglutarate is almost exclusively taken up by perivenous, glutamine-synthetase-containing hepatocytes. Eur J Biochem (1989) 181: 709-716.

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