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Children's Nutrition Research Center - Faculty

Houston, Texas

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Children's Nutrition Research Center - Faculty
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Paul Nakata, Ph.D.

Paul Nakata, Ph.D.Assistant Professor of Pediatrics, Baylor College of Medicine
Plant Biologist, Agricultural Research Service, U.S. Department of Agriculture

E-mail: pnakata@bcm.edu

Research Interests

Nutrient partitioning in plants and its manipulation for nutritional improvements of plant foods

My primary research interest is in elucidating the mechanisms regulating nutrient partitioning in plants and the manipulation of these mechanisms for nutritional improvement of plant foods. Current focus is to understand the mechanisms regulating calcium partitioning and sequestration in plants. To accomplish this goal, we are taking and integrated biochemical, cellular, molecular, and genetic approach to identify and characterize the components regulating calcium transport and storage. Such studies may lead to the rational design of strategies to enhance calcium abundance and bioavailability in plant foods.

Representative Publications

Foster, J, and Nakata, PA (2014) An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae. FEBS Letters 588:160-166

Punshon, T, Tappero, R, Ricachenevsky, FK, Hirschi, K, and Nakata, PA (2013) Contrasting calcium localization and speciation in leaves of the Medicago truncatula mutant cod5 analyzed via synchrotron X-ray techniques. The Plant Journal 76:627-633

Li, XK, Yang, J, Morris, J, Hester, A, Nakata, PA, and Hirschi, KD (2013) Genetically modified Medicago truncatula lacking calcium oxalate has increased calcium bioavailability and partially rescues Vitamin D receptor knockout mice phenotypes. J Bioequiv Availab 5:47-52

Nakata, Paul A. (2012) Engineering Calcium oxalate crystal formation in Arabidopsis. Plant Cell Physiol. 53(7): 1275-1282.

Nakata, Paul A (2012) Influence of calcium oxalate crystal accumulation on the calcium content of seeds from Medicago truncatula. Plant Science 185-186: 246-249.

Luo, Bin and Nakata, Paul A. (2012) A set of GFP organelle marker lines for intracellular localization studies in Medicago truncatula. Plant Science 188-189: 19-24.

Foster, Justin, Kim, Hyun-Uk, Nakata, Paul A., Browse, John (2012) A previously unknown oxalyl-CoA synthetase is important for oxalate catabolism in Arabidopsis. The Plant Cell 24:1217-1229.

Nakata, Paul A. (2012) Plant calcium oxalate crystal formation, function, and its impact on human health. Front. Biol. 7(3): 254-266

Nakata, Paul A. (2011) The oxalic acid biosynthetic activity of Burkholderia mallei is encoded by a single locus. Microbiological Research 166:531-538.

Nakata, Paul A. and He, Cixin (2010) Oxalic acid biosynthesis is encoded by an operon in Burkholderia glumae. FEMS Microbiol Lett 304: 177-182.

Park, Sang-Hyuck, Doege, Sarah J., Nakata, Paul A., Korth, Kenneth L (2009) Medicago truncatula-derived calcium oxalate crystals have a negative impact on chewing insect performance via their physical properties. Entomologia Experimentalis et Applicata 131: 208-215.

Morris, J, Nakata, PA, McConn, MM, Brock, A and Hirschi, KD (2007). Increased calcium bioavailability in mice fed genetically engineered plants lacking calcium oxalate. Plant Molecular Biology. 64:613-618.

Nakata, PA and McConn, MM (2007). Genetic evidence for differences in the pathways of druse and prismatic calcium oxalate crystal formation in Medicago truncatula. Functional Plant Biol. 34:332-338.

Nakata, PA and McConn, MM (2007). Calcium oxalate content affects the nutritional availability of calcium from Medicago truncatula leaves. Plant Science. 172:958-961.

Nakata, PA and McConn, MM (2007). Isolated Medicago truncatula mutants with increased calcium oxalate crystal accumulation have decreased ascorbic acid levels. Plant Physiology and Biochemistry. 45:216-220.

Nakata, PA and McConn, MM (2006). A genetic mutation that reduces calcium oxalate content increases calcium availability in Medicago truncatula. Functional Plant Biol. 33:703-706.

Korth, KL, Doege, SJ, Park, S-H, Goggin, FL, Wang, Q, Gomez, SK, Liu, G, Jia, L, Nakata, PA (2006). Medicago truncatula mutants demonstrate the role of plant calcium oxalate crystals as an effective defense against chewing insects. Plant Physiol. 141:188-195.

Franceschi, VR and Nakata, PA (2005). Calcium oxalate in plants: Formation and function. Annu. Rev. Plant Biol. 56:41-71.

McConn, MM and Nakata, PA (2004). Oxalate reduces calcium availability in the pads of the prickly pear cactus through formation of calcium oxalate crystals. J. Agric. and Food Chem. 52:1371-1374.

Kostman, TA, Franceschi, VR, and Nakata, PA (2003). Endoplasmic reticulum sub-compartments are involved in calcium sequestration within raphide crystal idioblasts of Pistia stratiotes, L. Plant Science 165:205-212. .

Nakata, PA (2003). Advances in our understanding of calcium oxalate crystal formation and function in plants. Plant Science 164:901-909.

Nakata, PA, Kostman, TA, and Franceschi, VR (2003). Calreticulin is enriched in the crystal idioblasts of Pistia stratiotes. Plant Physiol. and Biochem. 41:425-430.

Nakata, PA and McConn, MM (2003). Calcium oxalate crystal formation is not essential for growth of Medicago truncatula. Plant Physiol. and Biochem. 41:325-329.

Nakata, PA and McConn, MM (2003). Influence of the calcium oxalate defective 4 (cod4) mutation on the growth, oxalate, and calcium content of Medicago truncatula. Plant Science 164:617-621.

Nakata, PA and McConn, MM (2002). Sequential subtractive approach facilitates identification of differentially expressed genes. Plant Physiol. and Biochem. 40:307-312.

Nakata, PA (2002). The generation of a transposon-mutagenized Burkeholderia glumae library to isolate novel mutants. Plant Science 162:267-271.

McConn, MM and Nakata, PA (2002). Calcium oxalate crystal morphology mutants from Medicago truncatula. Planta 215:380-386.

Nakata, PA (2002). Calcium oxalate crystal morphology. Trends in Plant Science 7:324.

Nakata and McConn. Isolation of Medicago truncatula mutants defective in calcium oxalate formation. Plant Physiol, 2000; 124:1097-1104.

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