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Center for Cell and Gene Therapy

Houston, Texas

Center for Cell and Gene Therapy
Center for Cell and Gene Therapy
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Neuroblastoma

H26652; A Phase I/II Study Using Allogeneic Tumor Cell Vaccination with Oral Metronomic Cytoxan in Patients with High-Risk Neuroblastoma (ATOMIC): This study combines a genetically modified tumor cell vaccine with low dose oral cytoxan to treat patients with neuroblastoma.

H31493; Autologous Activated T-Cells Transduced with a 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase9 Safety Switch Administered to Patients with Relapsed or Refractory Neuroblastoma (GRAIN): This study uses T cells that have been transduced with a gene that creates an antibody called 14g2a. 14g2a is found on neuroblastoma cells lymphoma cells and helps the T cells find and kill the tumor. The T cells have also been transduced with the genes CD28 and OX40 both of which may help the T cells survive longer.

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