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Center for Cell and Gene Therapy

Houston, Texas

Center for Cell and Gene Therapy
Center for Cell and Gene Therapy
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Richard Hurwitz, M.D.

Richard HurwitzAssociate Professor
Department of Pediatrics
Section of Hematology-Oncology
Department of Molecular and Cellular Biology
Department of Ophthalmology
Baylor College of Medicine

E-mail: rhurwitz@bcm.edu
Phone: 832-824-4259

Education

M.D., Albany Medical College

Research Interests

Dr. Hurwitz is a Research Co-Director of the Retinoblastoma Center of Houston. In this capacity, Dr. Hurwitz is a member of a research and clinical team that is striving to improve the outcomes for children with retinoblastoma by reducing the morbidity and mortality associated with current treatment protocols. Dr. Hurwitz’ laboratory is involved in pre-clinical and translational studies designed to examine viral-mediated gene therapy for the treatment of ocular disorders including retinoblastoma. These studies include 1) elucidation of the unique properties of adenoviral transduction in the ocular environment; 2) investigation of immune consequences of adenoviral-mediated gene transfer; 3) elucidation of the differences between metastatic and non-metastatic tumor development; and 4) characterization of stem cell populations in retinoblastoma tumors and cell lines derived from those tumors.

Selected Publications

  • Hurwitz, R.L., Bunt-Milam, A.H., Chang M.L. and Beavo, J.A. (1985) cGMP phoshodiesterase in rod and cone outer segments of the retina. J. Biol. Chem. 260:568-573.
  • Hurwitz, R.L., Bogenmann, E., Font, R.L., Holcombe, V. and Clark, D. (1990) Expression of the functional cone phototransduction cascade in retinoblastoma. J. Clin. Invest. 85:1872-1878.
  • Suber, M., Pittler, S.J., Qin, N., Wright, G.C., Holcombe, V., Lee, R.H., Craft, C.M., Lolley, R.N., Baehr, W. and Hurwitz, R.L.(1993) Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase b subunit gene. Proc. Natl. Acad. Sci. 90:3968-3972.
  • Carcamo, B., Hurwitz, M.Y., Craft, C. and Hurwitz, R.L.(1995) The rat pineal expresses the cone but not the rod phosphodiesterase. J. Neurochem. 65:1085-1092.
  • Srivastava, D., Fox, D.A. and Hurwitz, R.L. (1995) The role of magnesium in the hydrolysis of cGMP by the bovine retinal rod cGMP phosphodiesterase. Biochem. J. 308:653-658.
  • Kommonen B, Kylma T, Cohen RJ, Penn JS, Hurwitz, MY, Hurwitz RL: Elevation of cGMP with normal expression and activity of rod cGMP phosphodiesterase in photoreceptor degenerate Labrador retrievers. Ophth Res. 28(1):19-28, 1996.
  • Hurwitz, MY, Marcus KT, Chévez-Barrios P, Louie K, Aguilar-Cordova CE, Hurwitz RL. Suicide gene therapy for treatment of retinoblastoma in a murine model. Human Gene Therapy. 10(3):441-448, 1999.
  • Chévez-Barrios P., Hurwitz MY, Louie K, Marcus KT, Holcombe VN, Schafer P, Aguilar-Cordova E, Hurwitz RL. Metastatic and non-metastatic models of retinoblastoma. American Journal of Pathology. 157:1405-1412, 2000.
  • Takahashi S., Rousseau R., Yotnda P., Mei Z., Dotti G., Rill D., Hurwitz R., Marini F., Andreeff M., Brenner M. Autologous antileukemic immune responses induced by chronic lymphocytic leukemia B cells expressing the CD-40 ligand and interleukin-2 transgenes. Human Gene Therapy. 12: 659-670, 2001.
  • Suber M.L., Hurwitz M.Y., Chévez-Barrios P., Hurwitz R.L. Immune consequences of intraocular administration of modified adenoviral vectors. Human Gene Therapy. 12: 833-838, 2001.
  • Hurwitz, R.L., Chevez-Barrios, P., Boniuk,M., Chintagumpala M., Hurwitz M.Y. Retinoblastoma: From Bench to Bedside In: Expert Reviews in Molecular Medicine, Cambridge Press, Cambridge, UK, 2003.
  • Chévez-Barrios P., Chintagumpala M., Mieler W., Boniuk M., Paysse E., Kozinetz C., Hurwitz M.Y., Hurwitz R.L. Response of Retinoblastoma with Vitreous Tumor Seeding to Adenovirus-mediated Delivery of Thymidine Kinase Followed by Ganciclovir. J Clin Onc. 23, 7927-7935, 2005.
  • Hurwitz, R.L., Shields, C., Shields, J., Chévez-Barrios, P., Hurwitz, M.Y. and Chintagumpala, M. Retinoblastoma In PA Pizzo and DG Poplack eds. Principles and Practice of Pediatric Oncology (5th edition). Lippincott-Raven, Philadelphia, 2006, pp 861-882.

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