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Center for Cell and Gene Therapy

Houston, Texas

Center for Cell and Gene Therapy
Center for Cell and Gene Therapy
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Mary (Joanne) Y. Hurwitz, Ph.D.

Mary Y. HurwitzAssociate Professor
Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine

E-mail: mhurwitz@bcm.edu
Phone: 832-824-4257

Education

Ph.D., University of Minnesota, Minneapolis, MN

Research Interests

Dr. Hurwitz is interested in the development and treatment of the ocular malignancy retinoblastoma. Studies are being conducted both in vitro and in vivo to define and characterize tumor initiating cell populations and to understand the growth of these tumors in the unique ocular environment. Innovative treatments using viral vectors to transfer potentially therapeutic genes into retinoblastoma are being examined in pre-clinical studies. In addition, Dr. Hurwitz is the principal investigator of the Texas Children's Cancer Center Tumor/Tissue Bank and directs the Research Tissue and Support Service for Texas Children's Hospital.

Selected Publications

  • Plummer, T.H., Jr. and Hurwitz, M.Y. Human plasma carboxypeptidase N: Isolation and characterization. J. Biol. Chem. 253:3907-3912, 1978.
  • Hurwitz, M.Y. and Edstrom, R.D. A simple, sensitive radioimmunoassay for 5'-nucleotidase. Analyt. Biochem. 84:246-250, 1978.
  • Hurwitz, M.Y., Hurwitz, R.L., and Edstrom, R.D. Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35. J. Enzyme Inhibition. 1:267-274, 1987.
  • Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McMullen, B., Hurwitz, M.Y., Krebs, E.G., and Wiggler, M. Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol. Cell. Biol. 7:1371-1377, 1987.
  • Hurwitz, M.Y., Putkey, J.A., Klee, C., and Means, A.R. Domain II of calmodulin is involved in activation of calcineurin. FEBS Letters. 238:82-86, 1988.
  • Rossen, R.D., Smith, C.W., Laughter, A.H., Noonan, C.A., Anderson, D.C., McShan, W.M., Hurwitz, M.Y., and Orson, F.M. HIV-1 stimulated expression of CD11/CD18 integrins and ICAM-1: A possible mechanism for extravascular dissemination of HIV-1 infected cells. Trans. of the Assoc. Am. Phys. 102:117-130, 1989.
  • Olson, N.J., Pearson, R.B., Needleman, D., Hurwitz, M.Y., Kemp, B.E., and Means, A.R. Regulatory and structural motifs of chicken gizzard myosin light chain kinase. Proc. Natl. Acad. Sci. USA. 87:2284-2288, 1990.
  • Hurwitz, R.L., Hirsch, K.M., Clark, D.J., Holcombe, V.N., and Hurwitz, M.Y. Induction of a calcium-calmodulin-dependent phosphodiesterase during PHA-stimulated lymphocyte mitogenesis. J. Biol. Chem. 265:8901-8907, 1990.
  • Sligh, J.E., Jr., Hurwitz, M.Y., Zhu, C., Anderson, D.C., and Beaudet, A.L. An initiation codon mutation in CD18 in association with the moderate phenotype of leukocyte adhesion deficiency. J. Biol. Chem. 267:714-718, 1992.
  • Carcamo, B., Hurwitz, M.Y., Craft, C.M., and Hurwitz, R.L. The pineal gland expresses the cone but not the rod cGMP phosphodiesterase. J. Neurochemistry. 65:1085-1092, 1995.
  • Hurwitz, R.L., Srivastava, D., and Hurwitz, M.Y. Channel structure and divalent cation regulation of phototransduction. Behavioral and Brain Sciences. 18:478, 1995.
  • Kommonen, B., Kylmä, T., Cohen, R.J., Penn, J.S., Paulin, L., Hurwitz, M.Y., and Hurwitz, R.L. Elevation of cGMP with normal expression and activity of rod cGMP-PDE in photoreceptor degenerate labrador retrievers. Ophthalmic Research. 28:19-28, 1996.
  • Kylma T, Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen, B. Cloning of the cDNA encoding rod photoreceptor cGMP phosphodiesterase a and g subunits from the retinal degenerate labrador retriever dog. Res Vet Sci. 62:293-296, 1997.
  • Kylma T, Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen, B. Cloning and analysis of the cDNA encoding the rod G-protein transducin a, b1 and g1 subunits from the canine retina. Gene. 193(1):1-4, 1997.
  • Hurwitz, M.Y., Marcus K.T., Chévez-Barrios P., Louie K., Aguilar-Cordova C.E., Hurwitz R.L. Suicide gene therapy for treatment of retinoblastoma in a murine model. Human Gene Therapy. 10(3):441-448, 1999.
  • Chévez-Barrios P., Hurwitz M.Y., Louie K., Marcus K.T., Holcombe V.N., Schafer P., Aguilar-Cordova E., Hurwitz R.L. Metastatic and non-metastatic models of retinoblastoma. American Journal of Pathology. 157(4):1405-1412, 2000.
  • Hurwitz R.L., Chévez-Barrios P., Chintagumpala M., Boniuk M., Hurwitz M.Y. Gene Therapy for Retinoblastoma. Proceedings of the 4th Great Basin Visual Science Symposium. 2000 vol 4.
  • Suber M.L., Hurwitz M.Y., Chévez-Barrios P., Hurwitz R.L. Immune consequences of intraocular administration of modified adenoviral vectors. Human Gene Therapy. 12: 833-838, 2001.
  • Hurwitz R.L., Shields C., Shields J., Chévez-Barrios P., Hurwitz, M.Y., Chintagumpala M. Retinoblastoma, In PA Pizzo and DG Poplack eds. Principles and Practice of Pediatric Oncology (4th edition). Lippincott-Raven, Philadelphia, 2002.
  • Hurwitz, R.L., Chevez-Barrios, P., Boniuk,M., Chintagumpala M., Hurwitz M.Y. Retinoblastoma: From Bench to Bedside In: Expert Reviews in Molecular Medicine, Cambridge Press, Cambridge, UK, 2003.
  • Chévez-Barrios P., Chintagumpala M., Mieler W., Boniuk M., Paysse E., Kozinetz C., Hurwitz M.Y., Hurwitz R.L. Response of Retinoblastoma with Vitreous Tumor Seeding to Adenovirus-mediated Delivery of Thymidine Kinase Followed by Ganciclovir. J Clin Onc. 23, 7927-7935, 2005.
  • Hurwitz, R.L., Shields, C., Shields, J., Chévez-Barrios, P., Hurwitz, M.Y. and Chintagumpala, M. Retinoblastoma In PA Pizzo and DG Poplack eds. Principles and Practice of Pediatric Oncology (5th edition). Lippincott-Raven, Philadelphia, 2006, pp 861-882.

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