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Dan L. Duncan Cancer Center

Houston, Texas

BCM has 25 departments and more than 90 research and patient-care centers.
Dan L. Duncan Cancer Center
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Hao Liu, Ph.D. - Associate Professor

Hao Liu, Ph.D. - Biostatistician

Division of Biostatistics, Dan L. Duncan Cancer Center
Department of Medicine, Section of Hematology/Oncology
Baylor College of Medicine, One Baylor Plaza, Houston, TX

Tel: 713-798-5586
Fax: 713-798-2716
E-mail: haol@bcm.edu

Education

2004 - Ph.D. – Biostatistics, University of Washington, Seattle, Washington
Certificate in Statistical Genetics, University of Washington, Seattle
1998 - M.A. – Biostatistics, University of California, Berkeley, California
1995 - B.S. – Mathematics, Peking University, Beijing, China

Previous Positions

2006 - 2011 - Assistant Professor, Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine
2004-2006 - Assistant Adjunct Professor, Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA
1998-2004 - Research/Teaching Assistant, Department of Biostatistics, University of Washington, Seattle, WA
2000 - Summer Intern, Genentech Inc., South San Francisco, CA
1996-1998 - Research Assistant, Division in Maternal and Child Health, School of Public Health, University of California, Berkeley, CA

Academic Awards

2005 - UC Davis Academic Federation Innovative Developmental Awards

Professional Memberships

2002 - Member, Institute of Mathematical Statistics
2004 - Member, American Statistical Association

Committee Memberships

2006 - Member, Texas Children’s Cancer Center Protocol Review Committee
2006 - Alternate member, Data Monitoring Committee, University of Texas, Houston M.D. Anderson Cancer Center
2007 - Member, IRB for Baylor College of Medicine and Affiliated Hospitals
2005 - External reviewer, Ph.D. dissertation, Statistics and Operations Research Department, Technical University of Catalonia, Barcelona, Spain

Peer Review Board

2007 - NIH/NCI Study Section, Early clinical trials of new anti-cancer agent with phase-1 emphasis (U01)

Referee

Journal of Clinical Oncology, Cancer Biotherapy & Radiopharmaceuticals, Biometrics, Annals of Statistics

Research Interests

  • Analysis of data in basic science experiments and clinical studies in cancer
  • Statistical methodology in time-to-event data
  • Design and analysis of preclinical study, phase I and phase II clinical trials in cancer
  • Analysis of Genomic and proteomic data in cancer

Research Grant Support

Current Research Support

Genentech Inc. Research Grants, Armin D. Weinberg, Ph.D., (PI)
Eliminating Disparities in Clinical Trials, Baylor College of Medicine, Houston, TX
Role: 10 percent Biostatistician. Feb. 1. 2007 - Jan. 31, 2009

NIH/NCI, C. Kent Osborne, M.D. (PI)
Cancer Center Support Grant P-30, Baylor College of Medicine, Houston, TX
The purpose of Resource is to support the research efforts of the Cancer Center through collaboration on biostatistical aspects of design, conduct, analysis and interpretation of clinical and basic science studies.
Role: 25 percent Biostatistician. July 1, 2007 - June 30, 2010

List of Past Graduate Students

Lei Wang, M.D., Ph.D. (2007), Graduate Group in Pharmacology and Toxicology, University of California, Davis (Ph.D. dissertation committee member).

Jingjing Ye, M.S., Ph.D. (2006), Graduate Group in Statistics, University of California, Davis (Ph.D. dissertation committee member).

Invited Presentations

Semiparametric Marginal Mean Models for Multiple-Type Recurrent Events, Seminar in the Department of Statistics, University of Nevada, Reno, April 12, 2007.

Bias in health effects model induced by source apportionment, EPA PM Center Workshop on Source Apportionment and Health Effects, Harriman, NY, May 2003.

A comparative study of the Genentech dynamic randomization method, Seminar in the Department of Biostatistics, Genentech Inc., South San Francisco, CA, September 2000.

Abstracts

Liu. H. A general semiparametric transformation model for survival data. Joint Statistical Meeting, Seattle, WA, August 6-10, 2006.

Wang, L., Liu, H. and Pinkerton, K. E. Acute and long-term effects of Secondhand Smoke (SHS) on the systemic immune system in young nonhuman primates, American Thoracic Society International Conference, San Diego, CA, May 19-24, 2006.

Liu. H. On semiparametric regression models for nonhomogeneous birth-birth process. 2006 Spring Meetings of the Eastern North American Region of the International Biometric Society, Tampa, FL, March 26-29, 2006.

Leiserowitz, G., Lebrilla, C., Miyamoto, S., An, H-J, Duong, H., Kirmiz, C., Liu, B-S, Liu, H., and Lam, K. Mass spectrometry glycomics analysis of serum: a potential new biomarker for ovarian cancer. Annual Meeting on Women’s Cancer, Society of Gynecologic Oncologists, Palm Springs, CA, March 22-26, 2006.

Liu, H., Beckett, L. A. and DeNardo, G. L. On the Analysis of Count Data for Molecular Targeted Cancer Therapy, the 11th Annual Cancer Research Symposium, Cancer Center, University of California, Davis, CA, October 27-28, 2005.

Liu, H., On regression models for birth-and-death process data, the 2005 joint WNAR/IMS meeting, University of Alaska, Fairbanks, Alaska, June 21-24, 2005.

Liu, H., Lumley, T. and Larson, T. On source apportionment and health effects models, the 2004 joint WNAR/IMS meeting, University of New Mexico, Albuquerque, NM, June 2004.

Publications

Gould, J. B., Sarnoff, R., Liu, H., Bell, D. R. and Chavez, G. (1999). Very low birth weight births at non-NICU hospitals: the role of sociodemographic, perinatal, and geographic factors, Journal of Perinatology 19(3), 197-205.

Gould, J. B., Benitz, W. E. and Liu, H. (2000). Mortality and time to death in very low birth weight infants: California, 1987 and 1993. Pediatrics 105(3), E37.

Yasui, Y., Liu, H., Benach, J. and Winget, M. (2000). An empirical evaluation of various priors in empirical Bayes estimation of small-area disease risks. Statistics in Medicine 19, 2409-2420.

Ulrich, C. M., Yasui, Y., Storb, R., Schubert, M. M., Wagner, J. L., Bigler, J., Ariail, K. S., Keener, C. L., Li, S., Liu, H., Farin, F. M. and Potter, J. D. (2001). Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood 98(1), 231-4.

Gould, J. B., Chavez, G., Marks, A. R. and Liu, H. (2002). Incomplete birth certificates: a risk marker for infant mortality. American Journal of Public Health 92(1), 79-81.

Wellner, J. A., Zhang, Y. and Liu, H. (2005). A semiparametric regression model for panel count data: when do pseudo-likelihood estimators become badly inefficient? In Proceedings of the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data. Lin, D.Y.; Heagerty, P.J. (Eds.), Springer-Verlag, New York, 2005.

Thurston, G. D., Ito, K., Mar, T., Christiansen, W. F., Eatough, D. J., Henry, R. C., Kim, E., Laden, F., Lall, R., Larson, T. V., Liu, H., Naes, L., Pinto, J., Stötzel, M., Suh, H. and Hopke, P. K. (2005). The Workshop on the Source Apportionment of PM Health Effects: Inter-Comparison of Results and Implications. Environmental Health Perspectives. 2005 Dec;113(12):1768-74.

Hopke PK, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu, H, Neas L, Pinto J, Stolzel M, Suh H, Paatero P, Thurston GD. (2006). PM source apportionment and health effects: 1. Intercomparison of source apportionment results. Journal of Exposure Analysis and Environmental Epidemiology. 2006 May;16(3):275-86.

An, H., Ninonuevo, M., Aguilan, J., Liu, H., Lebrilla, C. B., Alvarenga, L. S. and Mannis, M. J. (2006). Glycomic Analyses of Tear Fluid for the Diagnostic Detection of Ocular Rosacea. Journal of Proteome Research. 4 (6): 1981-1987

Nguyen, D. V., Liu, H. and Senturk, D. (2007). A general FDR-based computational framework for sample size planning in microarray studies. Chapter 3 in Advanced Computational Methods for Biocomputing and Bioimaging. Nova Science Publishers.

Liu, H., Beckett, L. A. and DeNardo, G. L. (2007). On the Analysis of Count Data of Birth-and-Death Process Type: with Application to Molecular Targeted Cancer Therapy. Statistics in Medicine. 26:1114-1135.

Wang, L., Joad J. P., Abel, K., Spinner, A., Liu, H. and Pinkerton, K. E. (2007). Effects of Environmental Tobacco Smoke on the Developing Immune System of Infant Monkeys. Journal of Allergy and Clinical Immunology. (In Press).

Leiserowitz, G., Lebrilla, C., Miyamoto, S., An, H. J., Duong, H., Kirmiz, C., Li, B., Liu, H. and Lam, K. (2007). Glycomics analysis of serum: a potential new biomarker for ovarian cancer? International Journal of Gynecological Cancer.

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