Breast Cancer Program
Jeffrey Rosen, Ph.D., Leader
Mo Rimawi, M.D., Co-Leader
The Breast Cancer Program includes 35 multidisciplinary investigators focusing on the biology, genetics, molecular pathology, diagnosis, prevention and treatment of breast cancer. Several faculty are also key members of other cancer center programs, ensuring inter-programmatic in addition to intra-programmatic interactions.
Twenty-one of the members are geographically and organizationally located in the Breast Center at Baylor College of Medicine and The Methodist Hospital. Other program members are located in the College's clinical and basic science departments, while maintaining a close working relationship with the Breast Center. Breast Cancer Program investigators are tied together in part by three large programmatic grants--a breast cancer SPORE and two program project grants-focusing on basic, translational and clinical research.
Clinical research includes investigator-initiated trials, trials directed by the NSABP and American College of Surgeons, and industry supported trials. The major theme of the Breast Cancer Program is to identify the genes and pathways important for breast cancer development and progression and then to translate that information to the bedside for improved diagnosis, treatment and prevention of the disease.
Within that framework, there are research programs in molecular profiling to determine prognosis and treatment response; molecular pathology of premalignant disease; estrogen receptors in disease pathogenesis and progression; molecular mechanisms of endocrine therapy resistance; growth factor signaling in breast cancer; novel pathways important in normal mammary gland development; cell cycle regulation; new strategies for breast cancer prevention; and targeted therapy for breast cancer treatment and prevention.
The Breast Cancer Program shares common interests and has significant interactions with several other cancer center programs including Cancer Prevention and Population Sciences, Nuclear Receptor Biology, and Cell and Gene Therapy.
Visit the Breast Center web site.