Welcome to Wang Laboratory
The advancements of high-throughput transcriptomic, genomic and deep sequencing technologies have generated a flood of data in the public domain and private warehouse. However, the laboratory discoveries based on the analysis of these data have met with limited success. Innovative computational technologies and integrated experimental approaches that can address the driving biological problems in cancer are of high demand.
Wang laboratory is a cancer genomics and molecular targeting lab at Lester & Sue Smith Breast Center and Dan L. Duncan Cancer Center, Baylor College of Medicine. The mission of this lab is to apply a multiple disciplinary approach inclusive of mathematics and statistics, computer science, bioinformatics, genomics, molecular and cell biology, and functional genomics to detect driving genetic aberrations and qualify appropriate cancer targets on the basis of the state-of-art high-throughput technologies.
The long-term goals of this laboratory are:
Develop innovative computational technologies to identify cancer genes and qualify appropriate targets that optimize the relevance of both biological context and the clinical situation.
Develop innovative functional genomics approach to high-throughput explore the biological significance of genetic and epigenetic aberrations and their role in therapeutic resistance in cancer.
Experimentally validate, characterize and confirm individual driver genetic and epigenetic aberrations, such as recurrent gene fusions, and oncogenes deregulated by genomic amplifications or epimutations.
Qualify tumor specific targets by lab approaches and clinical tests, including tumor specific antigens, membrane targets, autoantibody signatures, and biomarkers.