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Lester and Sue Smith Breast Center

Houston, Texas

The Lester and Sue Smith Breast Center's mission is to improve prevention, diagnosis and treatment of breast disease.
Lester & Sue Smith Breast Center
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Guidelines for Adjuvant Herceptin Cardiac Testing and Frequency of Administration

Suggested testing: 2-D Echocardiogram or MUGA

Frequency of cardiac testing:

  1. Healthy patients – no baseline prior to Adriamycin and Cytoxan (AC).
  2. Baseline for all patients – following AC and prior to initiation of Herceptin.
  3. For patients undergoing nine months of Herceptin alone, repeat testing every 4 months.
  4. For patients undergoing nine week treatment program of Herceptin, only the baseline testing is required. (Described in Kellokumpa-Lehtinin, J.H., et al. Trastuzamab in combination with docetaxel or vinorelbine as adjuvant treatment of breast cancer: the FinHer Trial. Proc SABCS 2005; 94 (Supp 1):S5 [abstract 2]).

Frequency of Herceptin administration:

  1. Routine administration will be every three weeks.
  2. For patient undergoing weekly Herceptin and a taxane, every three week Herceptin will be initiated at the completion of the weekly Herceptin/Taxane treatment. This will begin the week following the completion of the combined treatments.

Developed on Jan. 25, 2006 by:
Powel Brown, M.D.
Jenny Chang, M.D.
Richard Elledge, M.D.
Mamta Kalidas, M.D.
Rush Lynch, M.D.
Kent Osborne, M.D.
Suzanne Perez, RN, BSN
Mari Rude, RN, ANP

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