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Lester and Sue Smith Breast Center

Houston, Texas

The Lester and Sue Smith Breast Center's mission is to improve prevention, diagnosis and treatment of breast disease.
Lester & Sue Smith Breast Center
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Mothaffar F. Rimawi, M.D. - Publications

Selected Publications

Suleiman Massarweh, C. Kent Osborne, Chad Creighton, Lanfang Qin, Anna Tsimelzon, Shixia Huang, Heidi Weiss, Mothaffar Rimawi, and Rachel Schiff. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classical estrogen receptor genomic function. Cancer Res. 2008 Feb 1;68(3):826-33. [PDF]

Arpino, A., Gutierrez, C., Weiss, H., Rimawi, M., Massarweh, S., Bharwani, L., De Placido, S., Osborne, C.K., Schiff, R. Treatment of Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer Xenografts With Multiagent HER-Targeted Therapy. J Natl Cancer Inst. 2007 May 2;99(9):694-705. [PDF]

Massarweh, S., Osborne, C.K., Wakeling, A.E., Rimawi, M., Mohsin, S.K., Hilsenbeck, S., Schiff, R.: Mechanisms of tumor regression and acquired resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor positive, HER2/neu overexpressing breast cancer. Cancer Res 2006 Aug 15;66(16):8266-73. [PDF]

Schiff, R., Massarweh,S.A., Shou, J., Bharwani, L., Rimawi, M., Osborne, C.K. Advanced Concepts in Estrogen Receptor Biology and Breast Cancer Endocrine Resistance: Implicated Role of Growth Factor Signaling and Estrogen Receptor Coregulators. Cancer Chemother Pharmacol. 2005 Nov;56 Suppl 7:10-20. [PDF]

Rimawi, M.F., Shetty, P. ,Weiss, H.L. , Osborne, C.K., Chamness, G., Elledge, R.M. EGFR Expression in Breast Cancer: Association with biologic phenotype, prognosis, and clinical outcomes. (submitted JCO).

Rimawi, M.F.,Weiss, H.L., Arpino G, Morris, G.S., Soliz, R.D., Ward, R.M., Gilmer, T.M., Osborne, C.K., and Schiff, R: Potent inhibition of EGFR(ErbB1)/HER2 (ErbB2) pathway plus estrogen deprivation is a superior therapeutic combination in ER positive HER2-neu Over-expressing breast tumor xenografts. (Manuscript in preparation).

Abstracts and Presentations

Mothaffar F Rimawi, Heidi L Weiss, Grazia Arpino, Gay S Morris, Robert D Soliz, Robin M Ward, Tona M Gilmer, C K Osborne, and Rachel Schiff: Potent inhibition of EGFR(ErbB1)/HER2 (ErbB2) pathway plus estrogen deprivation is a superior therapeutic combination in ER positive HER2-neu Over-expressing breast tumor xenografts.
(Poster Discussion, San Antonio Breast Cancer Symposium 2006)

Rimawi MF, Weiss HL, Bhatia P, Chamness G, and Elledge RM: EGFR Expression in Breast Cancer: Association with biologic phenotype, prognosis, and resistance to adjuvant therapy. (Oral Presentation- Breast Cancer Session, ASCO 2006).

MF Rimawi, SK Mohsin, MC Gutierrez, G Arpino, SA Massarweh, JC Chang, CK Osborne and R Schiff: Inhibiting the growth factor receptor pathway preserves and enhances the expression of the estrogen receptor in HER-2/neu over-expressing human breast tumors and xenografts. (Oral Presentation, San Antonio Breast Cancer Symposium 2005).

Rimawi M.F., Massarweh, S.A., Ho, V.T., Popat, U., Lynch, G.R., Adult Cerebellar Medulloblastoma at Ben Taub General Hospital. ASCO Abstract, 2002.

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