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Lester and Sue Smith Breast Center

Houston, Texas

The Lester and Sue Smith Breast Center's mission is to improve prevention, diagnosis and treatment of breast disease.
Lester & Sue Smith Breast Center
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Michael T. Lewis, Ph.D. - Funding

Active

Title: Novel Gene Networks in Breast Development and Cancer, Project 4: The Ptc1 Hedgehog Receptor in Mammary Ductal Development and Progression to Neoplasia
Agency: NIH P01 CA30195
Role: PI (Osborne/Lewis)
Period: April 1, 2004 - March 31, 2009
The major goals of this large Program Project are to identify and characterize the role of novel genetic pathways, which are found to be important in the normal breast, in the pathogenesis and progression of human breast cancer. The goal of Project 4 is to determine the role of Ptc1 in these processes.

Title: Novel Gene Networks in Breast Development and Cancer, Animal Handling and Imaging Core
Agency: NIH P01 CA30195 (Osborne/Lewis)
Role: PI
Period: April 1, 2004 - March 31, 2009
The major goals of this large Program Project are to identify and characterize the role of novel genetic pathways, which are found to be important in the normal breast, in the pathogenesis and progression of human breast cancer. The goal of Core C is to provide for purchase and housing of animals, and to provide specialized surgical and imaging support for all 5 projects included in this Program Project.

Title: Hedgehog Signal Transduction Inhibitors in Breast Cancer Treatment and Prevention
Agency: Department of Defense (IDEA) 17 00 1 0477
Role: PI
Period: July 1, 2000 - June 30, 2005
The major goals of this project are to determine whether constitutive activation of hedgehog signaling can lead to mammary lesions in transgenic mice using an activated form of Smo that signals independently of hedgehogs and is unresponsive to Ptc-1 inhibition, to test the in vivo effect of specific hedgehog protein inhibitors on hedgehog network-induced lesions and the normal mammary gland, to test the in vivo effect of specific hedgehog protein inhibitors on hedgehog-independent lesions, and to test the effect of hedgehog inhibitors on the growth and morphology of human breast cancer cell lines in vitro.

Title: SPORE in Breast Cancer-Project 5: Genetic Expression Profile of Taxotere Versus AC Sensitivity
Agency: NIH (P50 CA58183)
Role: Co-Investigator
Period: Dec. 1, 2002 - Nov. 30, 2007
The main goal of this project is to identify, confirm and validate prospectively and retrospectively, two genetic pathways involved in the sensitivity and resistance of the two main treatment regimens in breast cancer, Taxotere (T) and Adriamycin plus cyclophosphamide (AC).

Title: Combining cell and gene therapy for treatment of early stage breast cancer
Agency: Department of Defense ( DAM.D.17-03-1-0571 )
Role: PI
Period: July 1, 2003 - June 30, 2004
The goal of this project is to define conditions under which genetically modified cells will persist when reintroduced to the mammary gland.

Title: Development of an Intraductal Cell and Gene Therapy Approach for Treatment of Early Stage Breast Cancer
Agency: Susan Love M.D. Breast Cancer Research Foundation
Role: PI
Period: July 1, 2003 - June 30, 2004
The goal of this pilot project is to perform a “proof of principle” experiment to determine whether a patient’s own breast cells can be removed, genetically modified to perform a therapeutic function, and reintroduced intraductally to survive long-term to combat cancer.

Title: Induction of mammary cancer by signaling molecules
Agency: NCI (R01 CA85736 Anderson, PI)
Role: Co-Investigator
Period: April 1, 2000 - March 31, 2005
The major goals of this project are to determine whether constitutive activation of either the prolactin receptor or one of its downstream effectors (Akt) will contribute to neoplastic progression or developmental defects in the mouse mammary gland.

Title: Functional Development of the Mammary Gland
Agency: NIH (PO1 HD38129 Neville, PI)
Role: Co-Project Leader/Animal Core Director
Period: July 1, 2000 - June 30, 2001 (June 30, 2005)

*Before relocating to Baylor College of Medicine, Dr. Lewis devoted 20 percent time as co-principal Investigator with Dr. Dean Edwards (UCHSC Department of Pathology) on a project to define the mechanisms of inhibition of milk secretion by progesterone during pregnancy and 20 percent time as the Animal Core director for the program project group. He continues to collaborate with the group from the University of Colorado.

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