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Lester and Sue Smith Breast Center

Houston, Texas

The Lester and Sue Smith Breast Center's mission is to improve prevention, diagnosis and treatment of breast disease.
Lester & Sue Smith Breast Center
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Yi Li, Ph.D. - Publications

Dunn, K. J., Williams, B. O., Li, Y., and Pavan, W. J. Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Proc Natl Acad Sci U S A, 97: 10050-10055, 2000.

Holland, E. C., Li, Y., Celestino, J., Dai, C., Schaefer, L., Sawaya, R. A., and Fuller, G. N. Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo. Am J Pathol, 157: 1031-1037, 2000.

Fisher, G. H., Orsulic, S., Holland, E., Hively, W. P., Li, Y., Lewis, B. C., Williams, B. O., and Varmus, H. E. Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene, 18: 5253-5260, 1999.

Li, Y., Hively, W. P., and Varmus, H. E. Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene, 19: 1002-1009, 2000.

Li, Y., Podsypanina, K., Liu, X., Crane, A., Tan, L. K., Parsons, R., and Varmus, H. E. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BioMedCentral: Mol Biol, 2: 2, 2001.

Dunn, K. J., Incao, A., Li, Y., and Pavan, W. J. In utero complementation of neural crest-derived melanocyte defect using cell directed gene transfer. Genesis, 30: 70-76, 2001.

Orsulic, S., Li, Y., Soslow, R. A., Vitale-Cross, L. A., Gutkind, J. S., and Varmus, H. E. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell, 1: 53-62, 2002.

Montaner, S., Sodhi, A., Molinolo, A., Bugge, T.H., Sawai, E.T., He, Y., Li, Y., Ray, P.E., and J.S. Gutkind (2002). Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell. 3:23-36, 2003.

Li,Y, Welm, B, Podsypanina, K., Huang, S, Chamorro, M., Zhang, X., Rowlands, R., Egeblad, M., Cowin, P., Werb, Z., Tan, L.K., Rosen, J.M., and Varmus, H.E., Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mouse mammary cancers from early cells in mammary development. Proc Natl Acad Sci U S A, 100: 15853-15858, 2003.

Sodhi A, Montaner S, Patel V, Gomez-Roman JJ, Li Y, Sausville EA, Sawai ET, Gutkind JS. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A, 101: 4821-4826, 2004.

Podsypanina, K., Li,Y., and Varmus, H.E., Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. BMC Medicine, 2:24, 2004.

Li, Y and Rosen, J.M. Stem/progenitor cells in mouse mammary gland development and breast cancer. J. Mammary Gland Biology & Neoplasia 10: 17-24. 2005.

Zhang X, Podsypanina K, Huang S, Mohsin SK, Chamness GC, Hatsell S, Cowin P, Schiff R, Li Y.. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene, 24: 4220-31. 2005.

Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum, M, Holland EC. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia, 7: 356-68. 2005.

Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE, Varmus HE. Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biology. 6:R84. 2005.

Grimm, S. L. W. Bu, M. A. Longley, D. R. Roop, Y. Li and J. M. Rosen. Keratin 6 is not essential for mammary gland development. Breast Cancer Research. 8(3): R29, 2006.

Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BO. The WNT signaling receptor, LRP5, is required for mammary ductal stem cell activity and WNT1-induced tumorigenesis. J. Biological Chemistry. 281: 35081-7. 2006.

Shixia Huang, Katrina Podsypanina, Yidong Chen, Weiyan Cai, Anna Tsimelzon, Susan Hilsenbeck, Yi Li. Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles. Technol Cancer Res Treat. 5: 565- 571, 2006.

Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y. Rapid induction of mammary tumorigenesis by somatic introduction of an oncogene into individual mammary epithelial cells in vivo. Proc Natl Acad Sci U S A, 103: 17396-17401, 2006.

Du & Li, RCAS-TVA in the mammary gland—an in vivo oncogene screen and a high fidelity model for breast transformation? Cell Cycle. 2007.

Lindvall, C., Bu, W, Williams, B. O., and Li, Y. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev. 3(2): 157-68. 2007.

Huang S, Chen Y, Podsypanina K, Li Y. High similarity in expression profiles between pulmonary metastases in either Wnt-1 or Neu transgenic model of breast cancer. Neoplasia. 10:118-24. 2008.

Stefan Siwko, Wen Bu, Carolina Gutierrez, Brian Lewis, Martin Jechlinger, Brian Schaffhausen, and Yi Li. Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors. Neoplasia 10: 653-62, 2008.

Siwko SK, Dong J, Lewis MT, Liu H, Hilsenbeck SG, Li Y. Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells—implications for pregnancy-induced protection against breast cancer. Stem Cells. Epub Sep 11, 2008.

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