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Microscopy

Houston, Texas

A view of cells
Integrated Microscopy Core, Department of Molecular and Cellular Biology
not shown on screen

Integrated Microscopy Core

Overview

The Integrated Microscopy Core, a shared resource in the Department of Molecular and Cellular Biology at Baylor College of Medicine, is a light and electron microscopy facility supporting BCM and the Texas Medical Center.

We gratefully acknowledge the support of the Center for Reproductive Biology, the Dan L. Duncan Cancer Center and the Texas Medical Center Digestive Diseases Center.

The IMC is equipped with:

  • Nikon A1-Rs inverted Laser Scanning Microscope with spectral detector and live cell environmental chamber.
  • DeltaVision (Deconvolution) Image Restoration Microscope capable of long term live cell imaging as well as automatic multiwell plate (96 or 384 well) imaging, equipped with two high-end digital CCD cameras for high resolution (CoolSNAP HQ) and fast, ultra high-sensitivity image collection (Cascade).
  • Hitachi H-7500 Transmission Electron Microscope (TEM)
  • DeltaVision (Deconvolution) Image Restoration Microscope
  • Zeiss Axioplan II upright microscope, for brightfield/darkfield imaging
  • Nikon TE-2000 inverted fluorescence microscope with multi-color imaging and DIC
  • Three fully automated high throughput microscopes (Beckman IC-100) for slides or multi-well plates
  • Fluid handling robot (Beckman BioMek NX)

The high throughput imaging resources are augmented by an Assay Development Service; access is based upon a brief proposal that is evaluated by an ad hoc committee. If interested in this new service supported in part by the Cancer Center, please contact Dr. Michael Mancini or Dr. Fabio Stossi directly.

The IMC also provides stand alone image analysis workstations with Applied Precision softWoRx, Imaris, Cytoshop, Metamorph, the new, fully customizable PipeLine Pilot suite of image analysis, reporting and statistics, and Spotfire. Additional services include TEM sample processing and ultramicrotomy, and software and microscopy training on all systems.

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