Positions
- Professor
-
Breast Center; Department of Molecular & Cellular Biology; Department of Molecular Virology & Microbiology
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Faculty Senator
-
Baylor College of Medicine
Houston, Texas United States
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Addresses
- BCM-Alkek Graduate School (Office)
-
Mail Stop: BCM600
Houston, TX 77030
United States
Phone: (713) 798-3963
liyi@bcm.edu
- BCM-Alkek Graduate School (Lab)
-
Mail Stop: BCM600
Houston, TX 77030
United States
Phone: (713) 798-3963
liyi@bcm.edu
Education
- BS from Jiangsu Agricultural College
- 07/1984 - Yangzhou, Jiangsu China, People's Rep
- MS from Jiangsu Agricultural College
- 07/1987 - Yangzhou, Jiangsu China, People's Rep
- PhD from Michigan State University
- 01/1996 - East Lansing, Michigan United States
- Postdoctoral Training at National Cancer Institute
- 01/2000 - Bethesda, Maryland United States
- Postdoctoral Training at Memorial Sloan Kettering Cancer Center
- 10/2002 - New York, New York United States
Professional Interests
- Breast cancer initiation and progression
- Wnt signaling and cancer stem cells
- Breast Cancer Prevention
- JAK-STAT signaling in breast cancer
Professional Statement
Dr. Yi Li studies breast cancer initiation and metastasis. His lab has developed multiple novel mouse and rat models that closely mimic human breast cancer initiation and progression. Using these models and cell biological, biochemical, genetic, and omic approaches, they have gained insights into Wnt-EGFR signaling in cancer progression, and discovered a JAK2-STAT5-regulated anti-apoptosis mechanism in promoting breast cancer development. Furthermore, their preclinical work on intermittent anti-JAK treatment for preventing breast cancer has resulted in a multi-center window-of-opportunity clinical trial (TBCRC042).Websites
Selected Publications
- Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y. "Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models." Proc Natl Acad Sci USA.. 2006 Nov;103(46):17396-401. Pubmed PMID: 17090666
- 32) Reddy, J.P., Peddibhotla, S., Bu, W., Zhao, J., Haricharan, S., Du, Y.C., Podsypanina, K., Rosen, J.M., Donehower, L.A. and Li, Y "Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation." PNAS. 2010;107(8):3728-33. Pubmed PMID: 20133707
- Jackson JG, Pant V, Li Q, Chang LL, Quintás-Cardama A, Garza D, Tavana O, Yang P, Manshouri T, Li Y, El-Naggar AK, Lozano G. "p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer." Cancer Cell.. 2012 Jun;21:793-806. Pubmed PMID: 22698404
- Haricharan S, Hein SM, Dong J, Toneff MJ, Aina OH, Rao PH, Cardiff RD, Li Y. "Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer.." Oncogene.. 2013 Dec 9; Pubmed PMID: 24317513
- Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. "Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy." eLIFE. 2013 Dec 31;2:e00996.
- Hatcher RJ, Dong J, Liu S, Bian G, Contreras A, Wang T, Hilsenbeck SG, Li Y, Zhang P. "Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.." Proc Natl Acad Sci USA.. 2014 Jan;111:1008-13. Pubmed PMID: 24395789
- Sinha, V.C., Qin, L. & Li, Y. "A p53/ARF-dependent Anticancer Barrier Activates Senescence and Blocks Tumorigenesis without Impacting Apoptosis." Molecular cancer research. 2014;13:231-8. Pubmed PMID: 25253740
- Zheng, Z.-Y., Tian, L., Bu, W., Fan, C., Gao, X., Wang, H., Liao, Y.-H., Li, Y., Lewis, M.T., Edwards, D., Zwaka, T.P., Hilsenbeck, S.G., Medina, D., Perou, C.M., Creighton, C.J., Zhang, X.H-F., & Chang, E.C "Wild type N-Ras, overexpressed in basal-like breast cancer, drives tumor formation by inducing IL8 secretion via JAK2 activation." Cell Reports. 2015;12:511. Pubmed PMID: 26166574
- Choi, S., Chen, Z., Tang, L.H., Fang, Y., Shin, S.J., Panarelli, N.C., Chen, Y.T., Li, Y., Jiang, X. & Du, Y.C "Bcl-xL promotes metastasis independent of its anti-apoptotic activity." Nat Commun. 2016;7:10384. Pubmed PMID: 26785948
- Hein, S.M., Haricharan, S., Johnston, A.N., Toneff, M.J., Reddy, J.P., Dong, J., Bu, W. & Li, Y "Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress." Oncogene. 2016;35:1461-7. Pubmed PMID: 26096929
- Dong, J., Zhao, W., Shi, A., Toneff, M., Lydon, J., & Li, Y. "The PR status of the originating cell of ER/PR-negative breast cancer." Oncogene. 2016;000. Pubmed PMID: 26640140
- Bu, W., Liu, Z., Jiang, W., Nagi, C., Huang, S., Edwards, D.P., Jo, E., Mo, Q., Creighton, C.J., Hilsenbeck, S.G., Leavitt, A.D., Lewis, M.T., Wong, S.T.C. & Li, Y "Mammary precancerous stem and non-stem cells evolve into cancers of distinct subtypes." Cancer Res. 2018 Oct 31; Pubmed PMID: 30401712
- Johnston, A.N., Bu, W., Hein, S., Garcia, S., Camacho, L., Xue, L., Qin, L., Nagi, C., Hilsenbeck, S.G., Kapali, J., Podsypanina, K., Nangia, J. and Li, Y. "Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions." Breast Cancer Res. 2018 May 19;20:42. Pubmed PMID: 29778097
- Zhang, W., Bado, I.L., Hu, J., Wan, Y.W., Wu, L., Wang, H., Gao, Y., Jeong, H.H., Xu, Z., Hao, X., Lege, B.M., Al-Ouran, R., Li, L., Li, J., Yu, L., Singh, S., Lo, H.C., Niu, M., Liu, J., Jiang, W., Li, Y. "The bone microenvironment invigorates metastatic seeds for further dissemination." Cell. 2021;184:2471-2486. Pubmed PMID: 33878291
- Yue F, Jiang W, Ku AT, Young AIJ, Zhang W, Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, Nagi C, Wang T, Hilsenbeck SG, Feng XH, Huang S, Coarfa C, Zhang XH, Liu Q, Lin X, Li Y. "A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis." Cancer Research. 2021;81:4441-4454.
- Young A, Bu W, Jiang W, Ku A, Kapali J, Dhamne S, Qin L, Hilsenbeck SG, Du YN, Li Y "Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer." Cancer Prevention Res. 2022;15(3-10)
- Lin, M., Ku, A.T., Dong, J., Yue, F., Jiang, W., Ibrahim, A.A., Peng, F., Creighton, C.J., Nagi, C., Gutierrez, C., Rosen, J.M., Zhang, X.H., Hilsenbeck, S.G., Chen, X., Du, Y.N., Huang, S., Shi, A., Fan, Z. & Li, Y. "STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential." Oncogene. 2022;41:5214-5222. Pubmed PMID: 36261627
- Ku, A.T., Young, A.I.J., Ibrahim, A.A., Bu, W., Jiang, W., Lin, M., Williams, L.C., McCue, B.L., Miles, G., Nagi, C., Behbod, F. & Li, Y "Short-term PI3K Inhibition Prevents Breast Cancer in Preclinical Models." Cancer Prevention Research. 2023;16:65-73. Pubmed PMID: 36343340
- Bu, W., Creighton, C.J., Heavener, K.S., Gutierrez, C., Dou, Y., Ku, A.T., Zhang, Y., Jiang, W., Urrutia, J., Jiang, W., Yue, F., Jia, L., Ibrahim, A., Zhang, B., Huang, S. & Li, Y "Efficient cancer modeling through CRISPR/Cas9/HDR-based somatic precision gene editing in mice." Science Adv. 2023;9(19):eade0059. Pubmed PMID: 37172086
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