Positions

Distinguished Service Professor
Department of Biochemistry and Molecular Biology
Baylor College of Medicine
Primary Appointment
The Alvin Romansky Chair in Biochemistry
Department of Biochemistry and Molecular Biology
Baylor College of Medicine
Secondary Appointment
Distinguished Service Professor
Department of Molecular Physiology and Biophysics
Baylor College of Medicine
Secondary Appointment
Distinguished Service Professor
Department of Molecular and Cell Biology
Baylor College of Medicine
Secondary Appointment
Distinguished Service Professor
Department of Molecular Virology and Microbiology
Baylor College of Medicine
Secondary Appointment

Education

Advanced Training from University Of California, Berkeley
Ph.D. from University Of California, Berkeley
B.A. from University Of California, Berkeley

Honors & Awards

Elected Member
Achievement Award
Elected Academician
Profiles in Excellence
Presidential Award
Chinese Biophysicists Network Award
Research Fellow
Alexander von Humboldt Research Prize
Clare Hall, Cambridge University
Guggenheim Fellow
Presidential Scholar
Award of Merit

Professional Interests

  • Bioinformatics
  • Nano Medicine and Drug Design
  • Cryo-Electron Microscopy and Tomography
  • Biophysics and Computational Biology
  • Protein Structure-Function and Protein Folding
  • Structural Biology and Macromolecular Assemblies
  • Membranes and Membrane Proteins
  • Molecular Basis of Human Disease and Behavior

Professional Statement

Our research interests are to determine 3-dimensional structures of biological nanomachines by electron cryomicroscopy and computer reconstruction and to relate the structures to their functional mechanisms. Our structural technique complements to those of X ray crystallography and NMR spectroscopy. Our laboratory is uniquely equipped with four intermediate voltage electron cryomicroscopes and supercomputer.

Our laboratory has pioneered various experimental and computational methods in biological cryo-EM. We have determined cryo-EM structures of biological bundle, ion channel, viruses and chaperonins at unprecedented resolutions. Our group has recently achieved the capability of tracing Ca backbone of protein components in several large molecular nanomachines using single particle cryo-EM without the aid of crystallography. Many of our structural investigations have produced not only novel structural informatics but also insightful functional mechanisms on protein folding and virus infection respectively.

Selected Publications

Memberships

National Academy of Sciences
The Academy of Medicine, Engineering, and Science of Texas
Baylor College of Medicine Alumni Association
University of Helsinki, Finland
Microscopy Society of America