University of Texas MD Anderson Cancer Center


BS from Georgetown University
PhD from Columbia University
Post-Doctoral Fellowship at Harvard Medical School

Professional Interests

  • Modeling human disease and development in the mouse

Professional Statement

Our laboratory is interested in elucidating genetic mechanisms that control normal development and are disrupted in pathological situations such as congenital birth defects and cancer. Current research interests are divided into three areas: dorsal-ventral limb patterning, ocular development and disease, and a novel tumor suppressor pathway called “Hippo” that was recently discovered in Drosophila. Our experimental approach is to generate mouse models that contain conditional and/or tagged alleles and to use these mice to study gain and loss of function phenotypes for critical regulators of mammalian growth and patterning.

Selected Publications