Positions

Assistant Professor
Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, Texas, United States
Cryo-EM modeling
Faculty Senator
Baylor College of Medicine
Houston, Texas, United States

Education

Post-Doctoral Fellowship at Baylor College Of Medicine
PhD from Baylor College Of Medicine
BS from Purdue University

Honors & Awards

Baylor Research Advocates for Student Scientists (BRASS) Scholar
Dunn Poster Award
Travel Award
Poster Award
Debra K. Martin Outstanding Graduate Student, SCBMB
Poster Award
Travel Award
Selected Poster
Selected Poster
Poster Award
Selected Poster

Professional Interests

  • Biophysics and Computational Biology
  • Cancer
  • Cryo-electron Microscopy and Tomography
  • Membranes and Membrane Proteins
  • Molecular Basis of Human Disease and Behavior
  • Nano Medicine and Drug Design
  • Protein Structure-Function and Protein Folding
  • Structural Biology and Macromolecular Assemblies
  • Animal Viruses
  • Bacteria and Phage

Professional Statement

Modeling Macromolecular Structure and Function From genome replication to viral infection, nearly all biological processes require a complex set of interactions, typically mediated by an ensemble of proteins. As such, these proteins, often organized as large, dynamic macromolecular complexes, are often the targets of structural biologists. Inspired by the structural and biochemical processes that govern macromolecular function, my research seeks to develop and apply novel approaches that combine computational modeling with macromolecular imaging from electron cryomicroscopy. To this end, my research has developed novel tools for pattern recognition, ab initio modeling, comparative modeling and de novo modeling using cryoEM density constraints. Our tools are distributed in our own molecular modeling toolkit, Gorgon, as well as part of the cryoEM image processing package, EMAN. In addition to technology development, my research also focuses on several key biological processes including immunotherapeutic approaches to treating cancer and viral maturation and infection.

Selected Publications

Intellectual Property

Chimeric Antigen Receptor For Bispecific Activation And Targeting Of T-Lymphocytes
Embodiments of the invention include methods and compositions related to improved cells encoding a chimeric antigen receptor that is specific for two or more antigens. In certain aspects the receptor encompasses two or more non-identical antigen recognition domains. The antigens are tumor antigens, in particular embodiments.
Co Inventors: Nabil Ahmed, Zakaria Grada, Meenakshi Hedge, Matthew Baker, Donald R. Shaffer