Positions

Scientist, Staff, Sr
Rice University (Current)
Houston, TX, US

Honors & Awards

3rd place Poster, HI 5001 Class poster
Dec 2005
Postdoctoral Poster Award
11th Sealy Structural Biology Symposium
May 2006
Poster Award
Salve Regina University, Newport, RI
June 2006
Pharmacoinformatics Training Program
T32
2005 - 2007
1st place Pharmacoinformatics Layperson Writing Contest
Oct 2006
2nd place Postdoctoral Oral Presentation Award
Nov 2006
Postdoctoral Poster Award
UTMB, Galveston, TX
May 2007
3rd place Postdoctoral Poster
Dec 2007
2nd place Postdoctoral Oral Presentation Award
Nov 2010
Travel Scholarship for "Topo2011" - Advances in DNA Topoisomerase and Chromosome Dynamics
Oct 2011
Travel Award for 4th Annual NGEC Workshop on Genome Engineering
Nov 2011

Professional Statement

Supercoiled DNA minivectors as a tool to study DNA structure, topoisomerases, and gene therapy

DNA inside all cells is slightly underwound or negatively supercoiled. In order to study DNA metabolism, we have generated small supercoiled DNA circles that we call minivectors. With these minivectors, as small as 250 bp, we are investigating the differences between overwound and underwound DNA, as well as the molecular mechanism and structure of human topoisomerase II-alpha, a major cancer drug target. In addition, we are exploring the utility of these minivectors as novel non-viral gene therapy vectors for the treatment of diseases, with particular interest in lung diseases. We have shown that these minivectors are remarkably resistant to serum nucleases and shear forces that are associated with gene therapy delivery.

Awards

Travel Award for 4th Annual NGEC Workshop on Genome Engineering, UW Medicine South Lake Union Campus, Seattle, WA (Nov 2011)

Travel Scholarship for "Topo2011" - Advances in DNA Topoisomerase and Chromosome Dynamics, Academia Sinica, Taipei, Taiwan (Oct 2011)

2nd place Postdoctoral Oral Presentation Award, Baylor College of Medicine Department of Molecular Virology and Microbiology Annual Retreat, Houston, TX (Nov 2010)

3rd place Postdoctoral Poster, Baylor College of Medicine Department of Molecular Virology and Microbiology Annual Retreat, Houston, TX (Dec 2007)

Postdoctoral Poster Award, 12th Sealy Structural Biology Symposium, UTMB, Galveston, TX (May 2007)

2nd place Postdoctoral Oral Presentation Award, Baylor College of Medicine Department of Molecular Virology and Microbiology Annual Retreat, Houston, TX (Nov 2006)

1st place Pharmacoinformatics Layperson Writing Contest, 16th Annual Keck Center Research Conference, Houston, TX (Oct 2006)

Training Slot with the Pharmacoinformatics Training Program of the W. M. Keck Center for Computational and Structural Biology of the Gulf Coast Consortia (T32) (2005 - 2007)

Poster Award, 75th Gordon Research Conference, Nucleic Acids, Salve Regina University, Newport, RI (June 2006)

Postdoctoral Poster Award, 11th Sealy Structural Biology Symposium, UTMB, Galveston, TX (May 2006)

3rd place Poster, HI 5001 Class poster, U.T. School of Health Information Sciences (Dec 2005)

2nd place Postdoctoral Poster, Baylor College of Medicine Department of Molecular Virology and Microbiology Annual Retreat, Houston, TX (Dec 2005)

2nd place Pharmacoinformatics Layperson Writing Contest, 15th Annual Keck Center Research Conference, Houston, TX (Oct 2005)

Professional Societies

Biophysics Society (2001-present)

American Chemical Society (2005-present)

Selected Publications

Memberships

Biophysics Society
2001-present
American Chemical Society
2005-present