Phone
Addresses
- Office
- BCM-MD Anderson Hall Room: BCMA-337E Mail Stop: BCM125 Houston, Texas 77030 United States
Websites
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Positions
- Assistant Professor
- Biochemistry-Songyang Lab
- Baylor College of Medicine
- Houston, TX, US
- Director
- Cell-based Assay Screening Service (C-BASS) core
- Baylor College of Medicine
- Houston, Texas, United States
- Co-Director, Cell-Based Assay Screening Shared Resource
- Dan L Duncan Comprehensive Cancer Center
- Baylor College of Medicine
- Houston, Texas, United States
Education
- Post-Doctoral Fellowship at Baylor College Of Medicine
- Biochemistry and Molecular Biology
- PhD from Tufts University School Of Medicine
- Immunology
- BS from Beijing University
- Ecology
Honors & Awards
- Postdoctoral Fellow
- The V.C. Joshi Memorial Award
Professional Statement
Cell Based Assay Screening Service (C-BASS) Core Facility
Genetic screens have been a powerful approach for defining signaling and developmental pathways in model organisms. However, such genetic strategies in mammalian systems have been hampered by a lack of tools. The emergence of RNAi as a tool for suppressing gene expression has invigorated the idea that such unbiased approaches can be applied to questions of human biology and disease. With the objective of facilitating BCM investigators in utilizing RNAi technologies, the Cell-based Assay Screening Service core provides instrumentation, resources, assistance, and advice for (1) performing whole-genome or sub-genome scale RNAi screens, (2) utilizing individual lentivirus-based shRNA vectors, (3) large-scale automated manipulation and preparation of shRNA libraries, (4) automated mammalian cell transfection and lentivirus production, (5) high-throughput cell-based assays using automated microscopy or flow cytometry, and (6) data analysis, storage, and management. To ensure optimal use of our services, we provide consultations and training for screen design, assay development, and data acquisition and analysis.
Selected Publications
- Fong KW, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. "Whole-genome screening identifies proteins localized to distinct nuclear bodies." J. Cell Biol.. 2013 October 14;203(1):149-64. Pubmed PMID: 24127217
- Shi FT, Kim H, Lu W, He Q, Liu D, Goodell MA, Wan M, Songyang Z. "Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells." J Biol Chem. 2013 July 19;288(29):20776-84. Pubmed PMID: 23729667
- Zhang Y, Chen LY, Han X, Xie W, Kim H, Yang D, Liu D, Songyang Z. "Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment." Proc Natl Acad Sci. 2013 April 2;110(14):5457-62. Pubmed PMID: 23509301
- Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. "MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis." J Cell Sci. 2013 February 1;126(3):825-37. Pubmed PMID: 23264731
- Wan M, Liang J, Xiong Y, Shi F, Zhang Y, Lu W, He Q, Yang D, Chen R, Liu D, Barton M, Songyang Z. "The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells." J Biol Chem. 2013 February 15;288(7):5039-48. Pubmed PMID: 23239880
- Lu W, Zhang Y, Liu D, Songyang Z, Wan M. "Telomeres-structure, function, and regulation." Exp Cell Res. 2013 January 15;319(2):133-41. Pubmed PMID: 23006819
- Xu J, Wan M, He Q, Bassett RL, Fu X, Chen AC, Shi F, Creighton CJ, Schiff R, Huo L, Liu D. "SGK3 is associated with estrogen receptor expression in breast cancer." Breast Cancer Res Treat. 2012 July;134(2):531-41. Pubmed PMID: 22576469
- Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF. "NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4." Nat Immunol. 2012 March 4;13(4):387-95. Pubmed PMID: 22388039
- King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, Goodell MA. "Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling." Blood. 2011 August 11;118(6):1525-33. Pubmed PMID: 21633090
- Liu D. "Analysis of average telomere length in cultured human cells.." Methods Mol. Biol.. 2011;735:13-9. Pubmed PMID: 21461807