Positions

Assistant Professor
Biochemistry-Songyang Lab
Baylor College of Medicine
Houston, TX, US
Director
Cell-based Assay Screening Service (C-BASS) core
Baylor College of Medicine
Houston, Texas, United States
Co-Director, Cell-Based Assay Screening Shared Resource
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Post-Doctoral Fellowship at Baylor College Of Medicine
Biochemistry and Molecular Biology
PhD from Tufts University School Of Medicine
Immunology
BS from Beijing University
Ecology

Honors & Awards

Postdoctoral Fellow
The V.C. Joshi Memorial Award

Professional Statement

Cell Based Assay Screening Service (C-BASS) Core Facility

Genetic screens have been a powerful approach for defining signaling and developmental pathways in model organisms. However, such genetic strategies in mammalian systems have been hampered by a lack of tools. The emergence of RNAi as a tool for suppressing gene expression has invigorated the idea that such unbiased approaches can be applied to questions of human biology and disease. With the objective of facilitating BCM investigators in utilizing RNAi technologies, the Cell-based Assay Screening Service core provides instrumentation, resources, assistance, and advice for (1) performing whole-genome or sub-genome scale RNAi screens, (2) utilizing individual lentivirus-based shRNA vectors, (3) large-scale automated manipulation and preparation of shRNA libraries, (4) automated mammalian cell transfection and lentivirus production, (5) high-throughput cell-based assays using automated microscopy or flow cytometry, and (6) data analysis, storage, and management. To ensure optimal use of our services, we provide consultations and training for screen design, assay development, and data acquisition and analysis.

Selected Publications